2-Hydroxy-5-(trifluoromethoxy)benzamide

Base Information

Chemical Name:2-Hydroxy-5-(trifluoromethoxy)benzamide
CAS No.:129644-59-3
Molecular Formula:C₈H₆F₃NO₃
Molecular Weight:221.136
Hs Code.:
DSSTox Substance ID:DTXSID501281456

Synonyms:2-hydroxy-5-(trifluoromethoxy)benzamide;129644-59-3;SCHEMBL9372777;JPEFKZOGWTXJBJ-UHFFFAOYSA-N;DTXSID501281456;MFCD12406876

Suppliers and Price of 2-Hydroxy-5-(trifluoromethoxy)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Hydroxy-5-(trifluoromethoxy)benzamide

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:221.02997754
Heavy Atom Count:15
Complexity:244

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1OC(F)(F)F)C(=O)N)O

Technology Process of 2-Hydroxy-5-(trifluoromethoxy)benzamide

There total 5 articles about 2-Hydroxy-5-(trifluoromethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid 2-chlorocarbonyl-4-trifluoromethoxy-phenyl ester

: 129644-59-3
2-Hydroxy-5-trifluoromethoxybenzamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.44.734

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 129644-59-3
2-Hydroxy-5-trifluoromethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / K₂CO₃ / 190 °C

2: Heating

3: oxalyl chloride / dimethylformamide; tetrahydrofuran / Ambient temperature

4: conc. aq. NH₃ / tetrahydrofuran / Ambient temperature

With ammonium hydroxide; oxalyl dichloride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.734

Reference yield:

: 129644-57-1
TFMSA

: 129644-59-3
2-Hydroxy-5-trifluoromethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: Heating

2: oxalyl chloride / dimethylformamide; tetrahydrofuran / Ambient temperature

3: conc. aq. NH₃ / tetrahydrofuran / Ambient temperature

With ammonium hydroxide; oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.734