2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

Base Information

Chemical Name:2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide
CAS No.:209725-88-2
Molecular Formula:C₈₀H₁₁₄N₁₂O₆
Molecular Weight:1339.86
Hs Code.:

2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

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Chemical Property of 2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

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Technology Process of 2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

There total 4 articles about 2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 612-76-0
1,1'-biphenyl-3,3'-diol

: 209725-88-2
2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / Cs₂CO₃ / dimethylformamide / 100 °C

2: 89 percent / TFA / CH₂Cl₂

3: 29 percent / EDC, DMAP / dimethylformamide / Ambient temperature

With dmap; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00651-0

Reference yield:

: 149411-94-9
2-(2-amino-6-(benzyloxy)-9H-purin-9-yl)acetic acid

: 209725-88-2
2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / tert-butyl nitrile, 60percent HF, pyridine / -42 °C

2: 37 percent / methanol / Ambient temperature

3: 29 percent / EDC, DMAP / dimethylformamide / Ambient temperature

With pyridine; dmap; Isobutyronitrile; hydrogen fluoride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00651-0

Reference yield:

: 209725-79-1
(6-Benzyloxy-2-fluoro-purin-9-yl)-acetic acid

: 209725-88-2
2-(6-Benzyloxy-2-octadecylamino-purin-9-yl)-N-[2-(3'-{2-[2-(6-benzyloxy-2-octadecylamino-purin-9-yl)-acetylamino]-ethoxy}-biphenyl-3-yloxy)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 37 percent / methanol / Ambient temperature

2: 29 percent / EDC, DMAP / dimethylformamide / Ambient temperature

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)00651-0