4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one

Base Information

• Chemical Name: 4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one
• CAS No.: 101072-41-7
• Molecular Formula: C₃₁H₂₇N₅O₅
• Molecular Weight: 549.586
• Mol file: 101072-41-7.mol

Synonyms:

Chemical Property of 4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one

There total 2 articles about 4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-trityluridine (6554-10-5) → 4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one (101072-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / KOH / dimethylsulfoxide / 1.5 h / Ambient temperature

2: 1.) POCl₃, (C₂H₅)3N / 1.) CH₃CN, 0 deg C -> room temp.; 2.) CH₃CN, room temp., 90 min.

With potassium hydroxide; triethylamine; trichlorophosphate; In dimethyl sulfoxide;

DOI:10.1055/s-1985-31332

Reference yield:

1,2,4-Triazole (288-88-0) + 2',3'-O-Methylene-5'-O-(triphenylmethyl)uridine (101072-39-3) → 4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one (101072-41-7)

Guidance literature:

With triethylamine; trichlorophosphate; Yield given. Multistep reaction; 1.) CH3CN, 0 deg C -> room temp.; 2.) CH3CN, room temp., 90 min.;

DOI:10.1055/s-1985-31332

Reference yield:

4-[1,2,4]Triazol-1-yl-1-((3aR,4R,6R,6aR)-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidin-2-one (101072-41-7) → 2',3'-O-Methylene-5'-O-(triphenylmethyl)-cytidine (101072-42-8)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; for 48h; Yield given; Ambient temperature;

DOI:10.1055/s-1985-31332

upstream raw materials:

1,2,4-Triazole

2',3'-O-Methylene-5'-O-(triphenylmethyl)uridine

5'-O-trityluridine

Downstream raw materials:

2',3'-O-Methylene-5'-O-(triphenylmethyl)-cytidine

4-N-Benzoyl-2',3'-O-methylenecytidine