[1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)-

Base Information

Chemical Name:[1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)-
CAS No.:1322001-36-4
Molecular Formula:C₁₈H₁₈FNO₃S
Molecular Weight:347.41
Hs Code.:
DSSTox Substance ID:DTXSID101153160

Synonyms:DTXSID101153160;[1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)-;1322001-36-4

Suppliers and Price of [1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:347.09914277
Heavy Atom Count:24
Complexity:527

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)S(=O)(=O)C2=CC=CC=C2C3=CC(=C(C=C3)C=O)F

Technology Process of [1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)-

There total 3 articles about [1,1'-Biphenyl]-4-carboxaldehyde, 3-fluoro-2'-(1-piperidinylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 248270-25-9
3-fluoro-4-formylphenylboronic acid

: 951883-98-0
1-(2-bromobenzenesulfonyl)piperidine

: 1322001-36-4
3-fluoro-2'-(piperidin-1-ylsulfonyl)biphenyl-4-carbaldehyde

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; In 1,2-dimethoxyethane; for 4h; Reflux; Inert atmosphere;
DOI:10.1021/jm2006035

Reference yield:

: 110-89-4
piperidine

: 1322001-36-4
3-fluoro-2'-(piperidin-1-ylsulfonyl)biphenyl-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / 1,2-dimethoxyethane / 4 h / Reflux; Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; 2: Suzuki coupling;
DOI:10.1021/jm2006035

Reference yield:

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 1322001-36-4
3-fluoro-2'-(piperidin-1-ylsulfonyl)biphenyl-4-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate / 1,2-dimethoxyethane / 4 h / Reflux; Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; 2: Suzuki coupling;
DOI:10.1021/jm2006035