5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

Base Information

Chemical Name:5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone
CAS No.:1331887-24-1
Molecular Formula:C₂₉H₂₂ClN₅O₄S
Molecular Weight:572.044
Hs Code.:

5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

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Chemical Property of 5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

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Technology Process of 5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

There total 3 articles about 5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1331887-20-7
1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-1H-indole-2,3-dione

: 556-90-1,884380-87-4
pseudothiohydantoin

: 1331887-24-1
5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

Guidance literature:: With sodium acetate; acetic acid; for 2h; Reflux;
DOI:10.1002/ardp.201100055

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1331887-24-1
5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: sodium acetate; acetic acid / 2 h / Reflux

With sodium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide; 2: Knoevenagel condensation;
DOI:10.1002/ardp.201100055

Reference yield:

: 766538-33-4
C₁₈H₁₆Cl₂N₂O₂

: 1331887-24-1
5-(1-{2-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydropyrazol-1-yl]-2-oxoethyl}-2-oxo-1,2-dihydroindol-3-ylidene)-2-amino-4-thiazolone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: sodium acetate; acetic acid / 2 h / Reflux

With sodium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide; 2: Knoevenagel condensation;
DOI:10.1002/ardp.201100055