Technology Process of 4'-(4-Methyl-bicyclo[2.2.2]oct-1-yl)-biphenyl-4-carbonitrile
There total 7 articles about 4'-(4-Methyl-bicyclo[2.2.2]oct-1-yl)-biphenyl-4-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / sodium hydroxide, water / 10 h / Heating
2: 63 percent / acetic anhydride / 14 h / Heating
3: 71 percent / potassium hydroxide, water / 6 h / 70 °C / Heating
4: 87 percent / 1.) hydrazine hydrate;2.) potassium hydroxide, diethylene glycol / 1.) reflux, 5 h; 2.) 230 deg C - 240 deg C, 20 h
5: 69 percent / zinc bromide, 50percent hydrobromic acid / 16 h / 60 - 70 °C / Heating
6: 67 percent / anhydrous aluminium chloride / nitrobenzene / 80 °C
7: 49 percent / 2.) anhydrous iron(III) chloride, cc. HCl / 1.) 1-methyl-2-pyrrolidone, 185 deg C, 3h; 2.) water, 50-60 deg C, 20 min
With
hydrogenchloride; potassium hydroxide; sodium hydroxide; aluminium trichloride; water; hydrogen bromide; acetic anhydride; iron(III) chloride; hydrazine hydrate; zinc dibromide; diethylene glycol;
In
nitrobenzene;
DOI:10.1039/P29810000026
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 63 percent / acetic anhydride / 14 h / Heating
2: 71 percent / potassium hydroxide, water / 6 h / 70 °C / Heating
3: 87 percent / 1.) hydrazine hydrate;2.) potassium hydroxide, diethylene glycol / 1.) reflux, 5 h; 2.) 230 deg C - 240 deg C, 20 h
4: 69 percent / zinc bromide, 50percent hydrobromic acid / 16 h / 60 - 70 °C / Heating
5: 67 percent / anhydrous aluminium chloride / nitrobenzene / 80 °C
6: 49 percent / 2.) anhydrous iron(III) chloride, cc. HCl / 1.) 1-methyl-2-pyrrolidone, 185 deg C, 3h; 2.) water, 50-60 deg C, 20 min
With
hydrogenchloride; potassium hydroxide; aluminium trichloride; water; hydrogen bromide; acetic anhydride; iron(III) chloride; hydrazine hydrate; zinc dibromide; diethylene glycol;
In
nitrobenzene;
DOI:10.1039/P29810000026
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 71 percent / potassium hydroxide, water / 6 h / 70 °C / Heating
2: 87 percent / 1.) hydrazine hydrate;2.) potassium hydroxide, diethylene glycol / 1.) reflux, 5 h; 2.) 230 deg C - 240 deg C, 20 h
3: 69 percent / zinc bromide, 50percent hydrobromic acid / 16 h / 60 - 70 °C / Heating
4: 67 percent / anhydrous aluminium chloride / nitrobenzene / 80 °C
5: 49 percent / 2.) anhydrous iron(III) chloride, cc. HCl / 1.) 1-methyl-2-pyrrolidone, 185 deg C, 3h; 2.) water, 50-60 deg C, 20 min
With
hydrogenchloride; potassium hydroxide; aluminium trichloride; water; hydrogen bromide; iron(III) chloride; hydrazine hydrate; zinc dibromide; diethylene glycol;
In
nitrobenzene;
DOI:10.1039/P29810000026
