2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Base Information

Chemical Name:2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester
CAS No.:85681-20-5
Molecular Formula:C₄₁H₄₄N₆O₉
Molecular Weight:764.835
Hs Code.:

2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Synonyms:

Suppliers and Price of 2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

There total 11 articles about 2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 15014-25-2
malonic acid dibenzyl ester

: 85681-18-1,85681-19-2
Methanesulfonic acid (S)-4-[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl ester

: 85681-20-5,85701-33-3
2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jo00160a008

Reference yield:

: 43077-06-1
6-N-benzoyl-2',3'-O-isopropylideneadenosine-5'-aldehyde

: 85681-20-5,85701-33-3
2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 68 percent / benzene; acetonitrile; CH₂Cl₂ / 1 h / 60 °C

2: 90 percent / H₂ / PtO₂ / ethanol / 50 h / 3102.9 Torr

3: 77 percent / ethane-1,2-diol / 6 h / 110 °C

4: NaOH / ethanol; H₂O / 1 h / 80 °C

5: imidazole / dimethylformamide / 5 h / Ambient temperature

6: 90 percent / NaOH, H₂O / tetrahydrofuran / 2 h / 0 °C

7: potassium tert-butoxide, oxalyl chloride / methanol; benzene / 0.5 h

8: 1.) sodium azide; / 1.) acetone, 0 deg C, 90 min.; 2.) reflux, 4h

9: 62 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / Ambient temperature

10: CH₂Cl₂; triethylamine / 1 h / Ambient temperature

11: 22 percent / NaH / dimethylformamide / 3 h / 80 °C

With 1H-imidazole; sodium hydroxide; sodium azide; oxalyl dichloride; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethylene glycol; triethylamine; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00160a008

Reference yield:

: 85681-03-4
(E)-N⁶-Benzoyl-2',3'-O-isopropylidene-5'-C-(2-oxotetrahydro-3-furanylidene)-5'-deoxyadenosine

: 85681-20-5,85701-33-3
2-{(S)-4-[(3aS,4S,6S,6aS)-6-(6-Amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-3-benzyloxycarbonylamino-butyl}-malonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / H₂ / PtO₂ / ethanol / 50 h / 3102.9 Torr

2: 77 percent / ethane-1,2-diol / 6 h / 110 °C

3: NaOH / ethanol; H₂O / 1 h / 80 °C

4: imidazole / dimethylformamide / 5 h / Ambient temperature

5: 90 percent / NaOH, H₂O / tetrahydrofuran / 2 h / 0 °C

6: potassium tert-butoxide, oxalyl chloride / methanol; benzene / 0.5 h

7: 1.) sodium azide; / 1.) acetone, 0 deg C, 90 min.; 2.) reflux, 4h

8: 62 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / Ambient temperature

9: CH₂Cl₂; triethylamine / 1 h / Ambient temperature

10: 22 percent / NaH / dimethylformamide / 3 h / 80 °C

With 1H-imidazole; sodium hydroxide; sodium azide; oxalyl dichloride; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethylene glycol; triethylamine; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00160a008