(1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester

Base Information

• Chemical Name: (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester
• CAS No.: 138336-38-6
• Molecular Formula: C₃₁H₄₂O₉S₂
• Molecular Weight: 622.801

Synonyms:

Chemical Property of (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester

There total 6 articles about (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester (138336-38-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / t-BuOK / tetrahydrofuran / 1 h / Ambient temperature

2: 91 percent / Oxone / methanol; H₂O / Ambient temperature

3: 1) NaH / 1) THF, rt, DMF, 2) 4 d, rt

4: 67 percent / DMAP, dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

5: 1) Na₂S₂O₄ / 1) THF, MeOH, water, rt, 1 h, 2) CH₂Cl₂, 10 deg C, then rt, 15 min

With dmap; Oxone; sodium dithionite; potassium tert-butylate; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jo00028a034

Reference yield:

(1R)-cis-hemicaronaldehydic acid (28075-68-5) → (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester (138336-38-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, rt, DMF, 2) 4 d, rt

2: 67 percent / DMAP, dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

3: 1) Na₂S₂O₄ / 1) THF, MeOH, water, rt, 1 h, 2) CH₂Cl₂, 10 deg C, then rt, 15 min

With dmap; sodium dithionite; sodium hydride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jo00028a034

Reference yield:

tert-butyl α-tert-butylthioacetate (49827-07-8) → (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester (138336-38-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / Oxone / methanol; H₂O / Ambient temperature

2: 1) NaH / 1) THF, rt, DMF, 2) 4 d, rt

3: 67 percent / DMAP, dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

4: 1) Na₂S₂O₄ / 1) THF, MeOH, water, rt, 1 h, 2) CH₂Cl₂, 10 deg C, then rt, 15 min

With dmap; Oxone; sodium dithionite; sodium hydride; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1021/jo00028a034

upstream raw materials:

diazomethane

<1R,1α,3α(E)>-(3-Phenoxyphenyl)methyl 2,2-Dimethyl-3-<3-tert-butoxy-2-(tert-butylsulfonyl)-3-oxo-1-propenyl>cyclopropanecarboxylate

bromoacetic acid tert-butyl ester

(1R)-cis-hemicaronaldehydic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 138336-38-6 (1R,3S)-3-[(1R,2R)-2-tert-Butoxycarbonyl-1-((S)-methoxysulfinyl)-2-(2-methyl-propane-2-sulfonyl)-ethyl]-2,2-dimethyl-cyclopropanecarboxylic acid 3-phenoxy-benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send