(2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime

Base Information

Chemical Name:(2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime
CAS No.:106986-22-5
Molecular Formula:C₂₇H₂₆F₃NO₃
Molecular Weight:469.504
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime

Chemical Property:

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Technology Process of (2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime

There total 14 articles about (2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119817-55-9
methyl 2-benzoylamino-2-phenyl-acetate

: 106986-22-5,106986-23-6,106986-24-7,106986-25-8
(2R,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / molecular sieve 4 Angstroem, 80 percent sodium hydride / tetrahydrofuran; paraffin / 48 h

2: 45 percent / triphenylphosphine, triethylamine, hexachloroethane / acetonitrile / 25 °C

3: 97 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h

4: 94 percent / 50 percent hypophosphorous acid, chromium(II) acetate / dimethylformamide / 0.25 h

5: 83 percent / hydroxylamine hydrochloride, pyridine / ethanol / 12 h / Heating

6: DCC, DMAP / CH₂Cl₂

With pyridine; dmap; hexachloroethane; 4 A molecular sieve; hydroxylamine hydrochloride; hydrogen; hypophosphorous acid; sodium hydride; chromium(II) acetate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; paraffin;
DOI:10.1016/S0040-4020(01)87623-7

Reference yield:

: 119817-55-9
methyl 2-benzoylamino-2-phenyl-acetate

: 106986-22-5,106986-23-6,106986-24-7,106986-25-8
(2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / molecular sieve 4 Angstroem, 80 percent sodium hydride / tetrahydrofuran; paraffin / 48 h

2: 45 percent / triphenylphosphine, triethylamine, hexachloroethane / acetonitrile / 25 °C

3: 97 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h

4: 94 percent / 50 percent hypophosphorous acid, chromium(II) acetate / dimethylformamide / 0.25 h

5: 83 percent / hydroxylamine hydrochloride, pyridine / ethanol / 12 h / Heating

6: DCC, DMAP / CH₂Cl₂

With pyridine; dmap; hexachloroethane; 4 A molecular sieve; hydroxylamine hydrochloride; hydrogen; hypophosphorous acid; sodium hydride; chromium(II) acetate; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; paraffin;
DOI:10.1016/S0040-4020(01)87623-7

Reference yield:

: 106986-10-1,106986-11-2
(1'R,2R/2S)-2,4-diphenyl-2-(1'-methyl-3'-phenyl-2'-propyn-1'-yl)-3-oxazolin-5-one

: 106986-22-5,106986-23-6,106986-24-7,106986-25-8
(2S,2'S),(E/Z)-O-<2'-methoxy-2'-(trifluoromethyl)phenylacetyl>-1,4-diphenyl-2-methylbutan-1-one oxime

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h

2: 94 percent / 50 percent hypophosphorous acid, chromium(II) acetate / dimethylformamide / 0.25 h

3: 83 percent / hydroxylamine hydrochloride, pyridine / ethanol / 12 h / Heating

4: DCC, DMAP / CH₂Cl₂

With pyridine; dmap; hydroxylamine hydrochloride; hydrogen; hypophosphorous acid; chromium(II) acetate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)87623-7