Technology Process of ethyl (Z)-4-[(2S,4S,6S)-6-{[(2R,4R,6R)-6-heptyl-2-phenyl-1,3-dioxan-4-yl]methyl}-2-phenyl-1,3-dioxan-4-yl]but-2-enoate
There total 13 articles about ethyl (Z)-4-[(2S,4S,6S)-6-{[(2R,4R,6R)-6-heptyl-2-phenyl-1,3-dioxan-4-yl]methyl}-2-phenyl-1,3-dioxan-4-yl]but-2-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate;
With
sodium hydride;
In
tetrahydrofuran; paraffin;
at -78 ℃;
for 1h;
2-[(2R,4R,6R)-6-{[(2R,4R,6R)-6-heptyl-2-phenyl-1,3-dioxan-4-yl]methyl}-2-phenyl-1,3-dioxan-4-yl]acetaldehyde;
In
tetrahydrofuran; paraffin;
at -78 ℃;
for 0.75h;
DOI:10.1002/ejoc.201100888
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol / toluene / 36 h / -15 °C / Molecular sieve
2.1: ozone / dichloromethane / 0.08 h / -78 °C
2.2: 18 h / 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 4 h / 0 °C
4.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / 20 °C
5.1: lithium aluminium tetrahydride; lithium iodide / 0.5 h / -100 - -40 °C
6.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 4 h / 20 °C
7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.5 h / 20 °C
7.2: 24 h / 20 °C
8.1: potassium tert-butylate / tetrahydrofuran / 6 h / 4 °C
9.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
10.1: sodium hydride / tetrahydrofuran; paraffin / 1 h / -78 °C
10.2: 0.75 h / -78 °C
With
2,6-dimethylpyridine; titanium(IV) isopropylate; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; potassium tert-butylate; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium hydride; diisobutylaluminium hydride; ozone; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethylene dibromide; toluene; acetonitrile; paraffin;
1.1: Keck allylation / 2.2: Wittig-Horner reaction / 7.1: Wittig-Horner reaction / 7.2: Wittig-Horner reaction / 8.1: Michael condensation / 10.2: Horner-Wittig reaction;
DOI:10.1002/ejoc.201100888
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride; lithium iodide / 0.5 h / -100 - -40 °C
2.1: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water / 4 h / 20 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 0.5 h / 20 °C
3.2: 24 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 6 h / 4 °C
5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran; paraffin / 1 h / -78 °C
6.2: 0.75 h / -78 °C
With
2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile; paraffin;
3.1: Wittig-Horner reaction / 3.2: Wittig-Horner reaction / 4.1: Michael condensation / 6.2: Horner-Wittig reaction;
DOI:10.1002/ejoc.201100888
![2-[(2R,4R,6R)-6-{[(2R,4R,6R)-6-heptyl-2-phenyl-1,3-dioxan-4-yl]methyl}-2-phenyl-1,3-dioxan-4-yl]acetaldehyde](/Databaselist/images/loading.webp)
