Corynoline

Base Information

Chemical Name:Corynoline
CAS No.:68035-45-0
Molecular Formula:C₂₁H₂₁NO₅
Molecular Weight:367.401
Hs Code.:
European Community (EC) Number:683-177-2
UNII:ZQ9W3JU6N3
DSSTox Substance ID:DTXSID20940272
Nikkaji Number:J34.215G
Wikipedia:Corynoline
Wikidata:Q15410919
Metabolomics Workbench ID:64048
ChEMBL ID:CHEMBL4126384

Synonyms:corynoline

Suppliers and Price of Corynoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Corynoline

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:0
Exact Mass:367.14197277
Heavy Atom Count:27
Complexity:603

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12C(CC3=CC4=C(C=C3C1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O
Isomeric SMILES:C[C@]12[C@H](CC3=CC4=C(C=C3[C@H]1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O

Technology Process of Corynoline

There total 22 articles about Corynoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 55739-69-0,55781-75-4,61615-96-1,61615-97-2,70160-42-8,74708-05-7,74708-07-9
4bα,5,6,10b,11,12-hexahydro-5,10bα-dimethyl-2,3;7,8-bis(methylenedioxy)benzophenathridine-11α,12α-diol

: 18797-79-0,51095-71-7,51151-82-7,68035-45-0,70191-84-3,74163-86-3,83607-66-3,83607-67-4,112438-07-0,114580-51-7
(+/-)-11-epicorynoline

Guidance literature:: With hydrogenchloride; perchloric acid; hydrogen; palladium on activated charcoal; at 50 ℃; for 24h; under 3800 Torr;

Reference yield: 53.0%

: 55739-69-0,55781-75-4,61615-96-1,61615-97-2,70160-42-8,74708-05-7,74708-07-9
4bα,5,6,10b,11,12-hexahydro-5,10bα-dimethyl-2,3;7,8-bis(methylenedioxy)benzophenathridine-11α,12β-diol

: 18797-79-0,51095-71-7,51151-82-7,68035-45-0,70191-84-3,74163-86-3,83607-66-3,83607-67-4,112438-07-0,114580-51-7
(+/-)-11-epicorynoline

Guidance literature:: With hydrogenchloride; perchloric acid; hydrogen; palladium on activated charcoal; at 50 ℃; for 24h; under 3800 Torr;

Reference yield:

: 1207-57-4
3,4-dihydro-2-methyl-6,7-methylenedioxynaphthalen-1(2H)-one

: 18797-79-0,51095-71-7,51151-82-7,68035-45-0,70191-84-3,74163-86-3,83607-66-3,83607-67-4,112438-07-0,114580-51-7
(+/-)-11-epicorynoline

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) titanium tetrachloride, 2.) triethylamine / 1.) chloroform, reflux, 1 h, 2.) benzene, 2 h

2: 20 percent / methanol / 16 h / Ambient temperature; Irradiation

3: 21 percent / hydrogen / palladium-charcoal / methanol / 2 h / 50 °C / 1900 Torr

4: 28 percent / dichlorodicyanobenzoquinone / CHCl₃ / 24 h / 4 °C

5: 1.) performic acid, 2.) sodium hydroxide / 1.) formic acid, room temperature, 1 h, 2.) methanol, reflux, 2 h

6: 83 percent / lithium aluminium hydride

7: 53 percent / hydrogen, hydrochloric acid, perchloric acid / palladium-charcoal / 24 h / 50 °C / 3800 Torr

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; perchloric acid; Peroxyformic acid; hydrogen; titanium tetrachloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; chloroform;