3-(2-methyl-3-methoxyphenyloxy) methyl ester

Base Information

Chemical Name:3-(2-methyl-3-methoxyphenyloxy) methyl ester
CAS No.:144864-81-3
Molecular Formula:C₂₃H₂₉NO₇
Molecular Weight:431.486
Hs Code.:

3-(2-methyl-3-methoxyphenyloxy)<N-t-butoxycarbonyl-(R)-4-methoxyphenylglycine> methyl ester

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Chemical Property of 3-(2-methyl-3-methoxyphenyloxy) methyl ester

Chemical Property:

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Technology Process of 3-(2-methyl-3-methoxyphenyloxy) methyl ester

There total 19 articles about 3-(2-methyl-3-methoxyphenyloxy) methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 144864-81-3
(S)-tert-Butoxycarbonylamino-[4-methoxy-3-(3-methoxy-2-methyl-phenoxy)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pivaloyl chloride, Et₃N, 2.) n-BuLi / 1.) THF, a) -78 deg C, 15 min, b) room temperature, 1 h, 2.) THF, a) -78 deg C, 25 min, b) room temperature, 20 h

2: 1.) 0.5 M potassium bistrimethylsilylamide, 2.) trisylazide / 1.) THF, -78 deg C, 23 min, 2.) THF, -78 deg C, 2 min

3: aq. LiOH / tetrahydrofuran / 0.58 h / 0 °C

4: p-toluenesulfonic acid / 5 h / Heating

5: H₂ / 10 percent palladium on activated carbon / ethyl acetate / 24 h / Ambient temperature

With lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/S0040-4020(01)90366-7

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 144864-81-3
3-(2-methyl-3-methoxyphenyloxy) methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) pivaloyl chloride, Et₃N, 2.) n-BuLi / 1.) THF, a) -78 deg C, 15 min, b) room temperature, 1 h, 2.) THF, a) -78 deg C, 25 min, b) room temperature, 20 h

2: 1.) 0.5 M potassium bistrimethylsilylamide, 2.) trisylazide / 1.) THF, -78 deg C, 23 min, 2.) THF, -78 deg C, 2 min

3: aq. LiOH / tetrahydrofuran / 0.58 h / 0 °C

4: p-toluenesulfonic acid / 5 h / Heating

5: H₂ / 10 percent palladium on activated carbon / ethyl acetate / 24 h / Ambient temperature

With lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/S0040-4020(01)90366-7

Reference yield:

: 34619-03-9
tert-butyldicarbonate

: 144864-81-3
3-(2-methyl-3-methoxyphenyloxy) methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent palladium on activated carbon / ethyl acetate / 24 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0040-4020(01)90366-7