2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>

Base Information

Chemical Name:2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>
CAS No.:133099-94-2
Molecular Formula:C₄₁H₃₈O₁₀
Molecular Weight:690.747
Hs Code.:

2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benz<f>indene-1',3'-dione>

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Chemical Property of 2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>

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Technology Process of 2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>

There total 10 articles about 2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2973-76-4
5-bromo-4-hydroxy-3-methoxybenzaldehyde

: 133099-94-2
2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>

Guidance literature:: Multi-step reaction with 10 steps

1: 1) Bu₄NI, NaH / 1) DMF, 10 min., r.t., 2) r.t., 24 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

3: 10percent aq.KOH / methanol / 12 h / 25 °C

4: 1) Bu₄NI, NaH / 1) DMF, r.t., 0.5 h, 2) 72 h, 25 deg C

5: 1) n-BuLi, 2) Cr(CO)6

6: 78 percent / K₂CO₃, Bu₄NI / acetone / 64 h / 55 °C

7: 89 percent / n-Bu₄NF / tetrahydrofuran / 14 h / 55 °C

8: 1) (COCl)2, DMSO, 2) Et₃N

9: 82 percent / NaOCH₃ / methanol / 5.5 h / 65 °C

10: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 1 h, 2) -78 deg C to r.t., 40 min.

With potassium hydroxide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; dimethyl sulfoxide; chromium⁽⁰⁾ hexacarbonyl; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo00006a029

Reference yield:

: 2363-14-6
5-Bromo-3-methoxy-4-(methoxymethoxy)benzene-1-carboxaldehyde

: 133099-94-2
2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>

Guidance literature:: Multi-step reaction with 9 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 16 h / Ambient temperature

2: 10percent aq.KOH / methanol / 12 h / 25 °C

3: 1) Bu₄NI, NaH / 1) DMF, r.t., 0.5 h, 2) 72 h, 25 deg C

4: 1) n-BuLi, 2) Cr(CO)6

5: 78 percent / K₂CO₃, Bu₄NI / acetone / 64 h / 55 °C

6: 89 percent / n-Bu₄NF / tetrahydrofuran / 14 h / 55 °C

7: 1) (COCl)2, DMSO, 2) Et₃N

8: 82 percent / NaOCH₃ / methanol / 5.5 h / 65 °C

9: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 1 h, 2) -78 deg C to r.t., 40 min.

With potassium hydroxide; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; dimethyl sulfoxide; chromium⁽⁰⁾ hexacarbonyl; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/jo00006a029

Reference yield:

: 133099-83-9
5-bromo-3-methoxy-4-(methoxymethoxy)phenol

: 133099-94-2
2,3-Dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<5',8'-bis(methoxymethoxy)-4',6'-dimethoxy-9'-(phenylmethoxy)-2'H-benzindene-1',3'-dione>

Guidance literature:: Multi-step reaction with 7 steps

1: 1) Bu₄NI, NaH / 1) DMF, r.t., 0.5 h, 2) 72 h, 25 deg C

2: 1) n-BuLi, 2) Cr(CO)6

3: 78 percent / K₂CO₃, Bu₄NI / acetone / 64 h / 55 °C

4: 89 percent / n-Bu₄NF / tetrahydrofuran / 14 h / 55 °C

5: 1) (COCl)2, DMSO, 2) Et₃N

6: 82 percent / NaOCH₃ / methanol / 5.5 h / 65 °C

7: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 1 h, 2) -78 deg C to r.t., 40 min.

With n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; dimethyl sulfoxide; chromium⁽⁰⁾ hexacarbonyl; triethylamine; In tetrahydrofuran; methanol; acetone;
DOI:10.1021/jo00006a029