(R^P,S^P)-O^P-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-O^P-(2-chlorphenyl)-2'-desoxy-N²-isobutyryl-5'-guanylsaeure

Base Information

• Chemical Name: (R^P,S^P)-O^P-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-O^P-(2-chlorphenyl)-2'-desoxy-N²-isobutyryl-5'-guanylsaeure
• CAS No.: 97892-94-9
• Molecular Formula: C₆₁H₅₉ClN₉O₁₄P
• Molecular Weight: 1208.62

Synonyms:

Chemical Property of (R^P,S^P)-O^P-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-O^P-(2-chlorphenyl)-2'-desoxy-N²-isobutyryl-5'-guanylsaeure

Chemical Property:

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Technology Process of (R^P,S^P)-O^P-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-O^P-(2-chlorphenyl)-2'-desoxy-N²-isobutyryl-5'-guanylsaeure

There total 5 articles about (R^P,S^P)-O^P-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-O^P-(2-chlorphenyl)-2'-desoxy-N²-isobutyryl-5'-guanylsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → (RP,SP)-OP-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-OP-(2-chlorphenyl)-2'-desoxy-N2-isobutyryl-5'-guanylsaeure (97892-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 4-(dimethylamino)pyridine / pyridine; dioxane / 3 h / Ambient temperature

2: tetrahydrofuran / 0.33 h / Ambient temperature

3: 1-methylimidazole / pyridine; tetrahydrofuran / 2 h

With 1-methyl-1H-imidazole; dmap; In tetrahydrofuran; 1,4-dioxane; pyridine;

Reference yield:

2-Amino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin (93366-96-2) → (RP,SP)-OP-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-OP-(2-chlorphenyl)-2'-desoxy-N2-isobutyryl-5'-guanylsaeure (97892-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) chlorotrimethylsilane / 1) pyridine, 15 min, r.t., 2) 3h, r.t.

2: 87 percent / 4-(dimethylamino)pyridine / pyridine; dioxane / 3 h / Ambient temperature

3: tetrahydrofuran / 0.33 h / Ambient temperature

4: 1-methylimidazole / pyridine; tetrahydrofuran / 2 h

With 1-methyl-1H-imidazole; dmap; chloro-trimethyl-silane; In tetrahydrofuran; 1,4-dioxane; pyridine;

Reference yield:

2-Acetylamino-7-(2-desoxy-β-d-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin (97892-89-2) → (RP,SP)-OP-<1-(2-Acetylamino-7H-pyrrolo<2,3-d>pyrimidin-7-yl)-5-O--2-desoxy-β-D-erythro-pentofuranosyl>-3'-O-benzoyl-OP-(2-chlorphenyl)-2'-desoxy-N2-isobutyryl-5'-guanylsaeure (97892-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 4-(dimethylamino)pyridine / pyridine; dioxane / 3 h / Ambient temperature

2: tetrahydrofuran / 0.33 h / Ambient temperature

3: 1-methylimidazole / pyridine; tetrahydrofuran / 2 h

With 1-methyl-1H-imidazole; dmap; In tetrahydrofuran; 1,4-dioxane; pyridine;

upstream raw materials:

3'-O-benzoyl-N²-isobutyryl-2'-deoxyguanosine

4,4'-dimethoxytrityl chloride

2-Amino-7-(2-desoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin

2-Acetylamino-7-(2-desoxy-β-d-erythro-pentofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin

Downstream raw materials:

C₅₅H₅₆N₉O₁₄P

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