(S)-2-methyl-3-phenylthio-1-propanol THP ether

Base Information

• Chemical Name: (S)-2-methyl-3-phenylthio-1-propanol THP ether
• CAS No.: 96882-96-1
• Molecular Formula: C₁₅H₂₂O₂S
• Molecular Weight: 266.404
• Mol file: 96882-96-1.mol

Synonyms:

Chemical Property of (S)-2-methyl-3-phenylthio-1-propanol THP ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methyl-3-phenylthio-1-propanol THP ether

There total 4 articles about (S)-2-methyl-3-phenylthio-1-propanol THP ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → (S)-2-methyl-3-phenylthio-1-propanol THP ether (96882-96-1)

Guidance literature:

Multi-step reaction with 4 steps

1: TsOH / tetrahydrofuran / Ambient temperature

2: 93.8 percent / LiAlH₄ / diethyl ether / 1.) 0 deg C, 40 min; 2.) RT

3: pyridine / 1.) 5 min; 0 deg C, 2.) 3 deg C, 1 d, 3.) 3 deg C, 1 d

4: 1.) NaOEt / 1.) EtOH, RT 2.) EtOH, reflux, 2.5 h 3.) RT

With pyridine; lithium aluminium tetrahydride; sodium ethanolate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4020(01)96497-X

Reference yield:

methyl 2(S)-methyl-3-tetrahydropyranyloxypropanoate (88557-53-3,135910-72-4,135910-76-8,96895-76-0) → (S)-2-methyl-3-phenylthio-1-propanol THP ether (96882-96-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93.8 percent / LiAlH₄ / diethyl ether / 1.) 0 deg C, 40 min; 2.) RT

2: pyridine / 1.) 5 min; 0 deg C, 2.) 3 deg C, 1 d, 3.) 3 deg C, 1 d

3: 1.) NaOEt / 1.) EtOH, RT 2.) EtOH, reflux, 2.5 h 3.) RT

With pyridine; lithium aluminium tetrahydride; sodium ethanolate; In diethyl ether;

DOI:10.1016/S0040-4020(01)96497-X

Reference yield:

(R)-3-(tetrahydro-2-pyranyloxy)-2-methyl-1-propanol (88728-99-8) → (S)-2-methyl-3-phenylthio-1-propanol THP ether (96882-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1.) 5 min; 0 deg C, 2.) 3 deg C, 1 d, 3.) 3 deg C, 1 d

2: 1.) NaOEt / 1.) EtOH, RT 2.) EtOH, reflux, 2.5 h 3.) RT

With pyridine; sodium ethanolate;

DOI:10.1016/S0040-4020(01)96497-X

upstream raw materials:

(S)-3-(tetrahydro-2-pyranyloxy)-2-methylpropyl p-toluenesulfonate

thiophenol

3,4-dihydro-2H-pyran

(R)-3-(tetrahydro-2-pyranyloxy)-2-methyl-1-propanol

Downstream raw materials:

(R)-2-methyl-1-(phenylsulfonyl)-3-(tetrahydropyranyloxy)propane

(S)-2-methyl-1-(phenylsulfonyl)-3-(tetrahydropyranyloxy)propane

Refernces