Technology Process of Benzo[5,6]phenanthro[4,3-f]quinoline
There total 5 articles about Benzo[5,6]phenanthro[4,3-f]quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-bromo-4-aza[6]helicene;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 0 ℃;
for 16h;
Reflux;
Inert atmosphere;
Schlenk technique;
With
TPEN;
In
tetrahydrofuran; dichloromethane;
for 0.0833333h;
Inert atmosphere;
Schlenk technique;
Sonication;
DOI:10.1021/acs.joc.9b00389
- Guidance literature:
-
3-bromo-4-aza[6]helicene; C25H14BrNZn;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 16h;
Inert atmosphere;
Schlenk technique;
Reflux;
With
TPEN;
In
tetrahydrofuran; diethyl ether; dichloromethane;
for 0.0833333h;
Inert atmosphere;
Schlenk technique;
Sonication;
DOI:10.1021/acs.joc.9b00389
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
1.2: 5 h / -78 - 20 °C / Inert atmosphere; Schlenk technique
2.1: iodine; methyloxirane / toluene / 15 h / 20 °C / Inert atmosphere; Schlenk technique; Irradiation
3.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; diethyl ether / 16 h / 0 °C / Inert atmosphere; Schlenk technique; Reflux
3.2: 0.08 h / Inert atmosphere; Schlenk technique; Sonication
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; iodine; methyloxirane;
In
tetrahydrofuran; diethyl ether; hexane; toluene;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 3.1: |Negishi Coupling;
DOI:10.1021/acs.joc.9b00389
