C₅₅H₅₉N₈O₆P

Base Information

• Chemical Name: C₅₅H₅₉N₈O₆P
• CAS No.: 1350970-57-8
• Molecular Formula: C₅₅H₅₉N₈O₆P
• Molecular Weight: 959.097
• Mol file: 1350970-57-8.mol

Synonyms:

Chemical Property of C₅₅H₅₉N₈O₆P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₅H₅₉N₈O₆P

There total 9 articles about C₅₅H₅₉N₈O₆P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1-naphthalenylethynyl)-2'-deoxyadenosine (1350970-54-5) → C55H59N8O6P (1350970-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 1 h / 60 °C

2: dmap / pyridine / 2 h / 20 °C

3: triethylamine / acetonitrile / 0.33 h / 20 °C

With dmap; triethylamine; In pyridine; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.09.104

Reference yield:

2'-Deoxyguanosine (961-07-9) → C55H59N8O6P (1350970-57-8)

Guidance literature:

Multi-step reaction with 10 steps

1: dmap; triethylamine / acetonitrile / 0.08 h / 20 °C

2: N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate / acetonitrile / 0.17 h / 85 °C

3: copper(l) iodide; diiodomethane; 2-Trimethylsilylimidazole; isopentyl nitrite / tetrahydrofuran / 0.33 h / Reflux

4: methanol; ammonia / 16 h / 60 °C

5: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 0.33 h / 80 °C

6: potassium carbonate / methanol / 2 h / 20 °C

7: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 0.25 h / 80 °C / Inert atmosphere

8: N,N-dimethyl-formamide / 1 h / 60 °C

9: dmap / pyridine / 2 h / 20 °C

10: triethylamine / acetonitrile / 0.33 h / 20 °C

With methanol; dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diiodomethane; N-benzyl-N,N,N-triethylammonium chloride; ammonia; potassium carbonate; N,N-dimethyl-aniline; triethylamine; 2-Trimethylsilylimidazole; trichlorophosphate; isopentyl nitrite; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.09.104

Reference yield:

2-iodo-9-<2-deoxy-β-D-ribofuranosyl>adenine (118706-49-3) → C55H59N8O6P (1350970-57-8)

Guidance literature:

Multi-step reaction with 6 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 0.33 h / 80 °C

2: potassium carbonate / methanol / 2 h / 20 °C

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 0.25 h / 80 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 1 h / 60 °C

5: dmap / pyridine / 2 h / 20 °C

6: triethylamine / acetonitrile / 0.33 h / 20 °C

With dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2011.09.104

upstream raw materials:

C₂₅H₂₄N₆O₃

6-chloro-2-iodo-9-(3',5'-di-O-acetyl-2'-deoxy-β-D-ribofuranosyl)purine

C₁₅H₂₁N₅O₃Si

2-(1-naphthalenylethynyl)-2'-deoxyadenosine