(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene

Base Information

• Chemical Name: (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene
• CAS No.: 137548-46-0
• Molecular Formula: C₃₈H₇₁O₃PSi₂
• Molecular Weight: 663.125
• Mol file: 137548-46-0.mol

Synonyms:

Chemical Property of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene

There total 1 articles about (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3aR,7aR)-1-[(R)-4-(Dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-inden-4-one (122805-16-7) + [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide (81522-68-1) → (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene (137548-46-0)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction;

DOI:10.1016/S0040-4039(00)92270-6

Reference yield: 83.0%

(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-1-[(R)-4-(dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-indene (137548-46-0) → 1α-hydroxy-25-oxo-25-phosphavitamin D3 (137548-43-7)

Guidance literature:

With tetrabutyl ammonium fluoride;

DOI:10.1016/S0040-4039(00)92270-6

upstream raw materials:

(1R,3aR,7aR)-1-[(R)-4-(Dimethyl-phosphinoyl)-1-methyl-butyl]-7a-methyl-octahydro-inden-4-one

[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Downstream raw materials:

1α-hydroxy-25-oxo-25-phosphavitamin D₃