(2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate

Base Information

Chemical Name:(2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate
CAS No.:92512-39-5
Molecular Formula:C₃₆H₅₂O₆SSi
Molecular Weight:640.957
Hs Code.:

Synonyms:

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Chemical Property of (2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate

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Technology Process of (2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate

There total 7 articles about (2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2,4,6-tri-isopropylbenzenesulphonyl chloride

: 92512-38-4,102778-93-8
(2S,4S)-1-(Diphenyl-t-butylsilyloxy)pentane-2,4,5-triol

: 92512-39-5
(2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate

Guidance literature:: With pyridine; for 40h; Ambient temperature;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 92512-39-5
(2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) imidazole, 2.) pyridine / 1.) N,N-dimethylformamide, room temperature, overnight, 2.) room temperature, overnight

2: 89 percent / DBU / tetrahydrofuran / 0.75 h / 0 °C

3: 1.) DBU, 2.) H₂ / 2.) 10percent palladium on carbon / 1.) THF, 0 deg C, 20 min, 2.) ethanol, overnight

4: 89 percent / boric acid, sodium borohydride, Amberlyte IR 120H+ resin / tetrahydrofuran; H₂O / 2.5 h / 20 - 30 °C

5: 84 percent / pyridine / 40 h / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; Amberlyte IR 120H+ resin; hydrogen; boric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; water;

Reference yield:

: 5336-08-3
D-Ribono-1,4-lactone

: 92512-39-5
(2S,4S)-5-diphenyl-t-butylsilyloxy-2,4-dihydroxypentyl 2,4,6-tri-isopropylbenzenesulphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) imidazole, 2.) pyridine / 1.) N,N-dimethylformamide, room temperature, overnight, 2.) room temperature, overnight

2: 89 percent / DBU / tetrahydrofuran / 0.75 h / 0 °C

3: 1.) DBU, 2.) H₂ / 2.) 10percent palladium on carbon / 1.) THF, 0 deg C, 20 min, 2.) ethanol, overnight

4: 89 percent / boric acid, sodium borohydride, Amberlyte IR 120H+ resin / tetrahydrofuran; H₂O / 2.5 h / 20 - 30 °C

5: 84 percent / pyridine / 40 h / Ambient temperature

With pyridine; 1H-imidazole; sodium tetrahydroborate; Amberlyte IR 120H+ resin; hydrogen; boric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; water;