H-Ala2-Phe-m-aB-Ile-Val-OMe

Base Information

Chemical Name:H-Ala2-Phe-m-aB-Ile-Val-OMe
CAS No.:149381-36-2
Molecular Formula:C₄₂H₅₆N₆O₈
Molecular Weight:772.942
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-Ala2-Phe-m-aB-Ile-Val-OMe

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Technology Process of H-Ala2-Phe-m-aB-Ile-Val-OMe

There total 12 articles about H-Ala2-Phe-m-aB-Ile-Val-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 149381-26-0
Boc-Ala2-Phe-m-aB-Ile-Val-OMe

: 149381-36-2
H-Ala2-Phe-m-aB-Ile-Val-OMe

Guidance literature:: With sodium hydrogencarbonate; trifluoroacetic acid; 1) CH₂Cl₂, 0 deg C, 2) EtOAc;

Reference yield:

: 129229-78-3
2-phenoxymethyl-5-nitrobenzoic acid

: 149381-36-2
H-Ala2-Phe-m-aB-Ile-Val-OMe

Guidance literature:: Multi-step reaction with 11 steps

1: H₂ / PtO₂ / methanol; dimethylformamide / 2 h / Ambient temperature

2: NEt₃ / H₂O; dioxane / 1) 0 deg C to RT, 30 min, 2) RT, overnight

3: 86 percent / NaH / tetrahydrofuran / 48 h / Ambient temperature

4: 96 percent / NEt₃, hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂; tetrahydrofuran / 1) 0 deg C, 2 h, 2) RT, overnight

5: 65 percent / HCl / ethyl acetate / 3.5 h / 0 °C

6: 92 percent / ethyl acetate / Ambient temperature

7: 89 percent / CH₂Cl₂ / Ambient temperature

8: 48 percent / Boc-L-alanine, NMM, HOBt, DCC / CH₂Cl₂; tetrahydrofuran / 1) 0 deg C, 2 h, 2) RT, overnight

9: 40 percent / HCl / ethyl acetate / 1) 0 deg C, 1.5 h, 2) RT, 1 h

10: 85 percent / N-methylmorpholine, hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂; tetrahydrofuran / 1) 0 deg C, 2 h, 2) RT, overnight

11: 86 percent / 1) TFA, 2) NaHCO₃ / 1) CH₂Cl₂, 0 deg C, 2) EtOAc

With 4-methyl-morpholine; hydrogenchloride; L-N-Boc-Ala; hydrogen; sodium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 33294-54-1
N-t-butoxycarbonyl-L-phenylalanine anhydride

: 149381-36-2
H-Ala2-Phe-m-aB-Ile-Val-OMe

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / ethyl acetate / Ambient temperature

2: 89 percent / CH₂Cl₂ / Ambient temperature

3: 48 percent / Boc-L-alanine, NMM, HOBt, DCC / CH₂Cl₂; tetrahydrofuran / 1) 0 deg C, 2 h, 2) RT, overnight

4: 40 percent / HCl / ethyl acetate / 1) 0 deg C, 1.5 h, 2) RT, 1 h

5: 85 percent / N-methylmorpholine, hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂; tetrahydrofuran / 1) 0 deg C, 2 h, 2) RT, overnight

6: 86 percent / 1) TFA, 2) NaHCO₃ / 1) CH₂Cl₂, 0 deg C, 2) EtOAc

With 4-methyl-morpholine; hydrogenchloride; L-N-Boc-Ala; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate;