[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester

Base Information

• Chemical Name: [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester
• CAS No.: 869893-58-3
• Molecular Formula: C₄₈H₇₂O₈Si
• Molecular Weight: 805.18

Synonyms:

Chemical Property of [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Useful:

Technology Process of [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester

There total 8 articles about [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((5S,8R,9S,10S,13S,14S)-10,13-dimethyl-3-oxo-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester (869893-57-2) → [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester (869893-58-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2005.08.085

Reference yield:

2-[2-[2-[2-[2-[tert-butyl(diphenyl)silyl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethanol (615261-85-3) → [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester (869893-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 43 percent / Jones reagent / acetone / 0.5 h / 20 °C

2: 58 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl salt / CH₂Cl₂ / 16 h

3: borane - methylsulfide complex / tetrahydrofuran / 1 h / 0 °C

With dmap; jones reagent; dimethylsulfide borane complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1016/j.tet.2005.08.085

Reference yield:

2,2-dimethyl-3,3-diphenyl-4,7,10,13,16-pentaoxa-3-silaoctadecan-18-oic acid (209542-21-2) → [2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester (869893-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / 4-(dimethylamino)pyridine; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl salt / CH₂Cl₂ / 16 h

2: borane - methylsulfide complex / tetrahydrofuran / 1 h / 0 °C

With dmap; dimethylsulfide borane complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2005.08.085

upstream raw materials:

[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((5S,8R,9S,10S,13S,14S)-10,13-dimethyl-3-oxo-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propyl ester

2-[2-[2-[2-[2-[tert-butyl(diphenyl)silyl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethanol

2,2-dimethyl-3,3-diphenyl-4,7,10,13,16-pentaoxa-3-silaoctadecan-18-oic acid

Pentaethylene glycol

Downstream raw materials:

[2-(2-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid (S)-2-((3S,5S,8R,9S,10S,13S,14S,17R)-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-propyl ester

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