chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

Chemical Name:chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
CAS No.:34582-77-9
Molecular Formula:C₂₀H₁₉Cl₂N₃O₅S
Molecular Weight:484.36
Hs Code.:

chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Chemical Property of chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Technology Process of chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 2 articles about chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34582-77-9
6β-[3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carbonylamino]-penicillanic acid chloromethyl ester

Guidance literature:: entspr. Penicillansaeure-Na-Salz, CH2ClI;

Reference yield:

: 34582-77-9
(2S,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid chloromethyl ester

Guidance literature:: aus Isoxazolylpenicillin, C19H18ClN3O5S, ClCH2J;

Reference yield:

: 34582-77-9
chloromethyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 122648-70-8
<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-6-<<3-(2-chlorophenyl)-5-methyl-4-isoxazolyl>carboxamido>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.2 g / dimethylformamide / 144 h / Ambient temperature

2: 0.45 g / nitromethane

3: 0.13 g / Na₂S₂O₄, NaHCO₃

With sodium dithionite; sodium hydrogencarbonate; In nitromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00128a021