3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole

Base Information

• Chemical Name: 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole
• CAS No.: 100241-93-8
• Molecular Formula: C₁₃H₁₆N₂OS
• Molecular Weight: 248.349
• Mol file: 100241-93-8.mol

Synonyms:

Chemical Property of 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole

There total 3 articles about 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-methoxy-5-(chloromethyl)isothiazole (91989-71-8) + benzyl-methyl-amine (103-67-3) → 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole (100241-93-8)

Guidance literature:

In methanol; for 24h; Ambient temperature;

Reference yield:

5-(hydroxymethyl)-3-methoxyisothiazole (100241-92-7) → 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole (100241-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / SOCl₂ / 0.75 h / Heating

2: 85 percent / methanol / 24 h / Ambient temperature

With thionyl chloride; In methanol;

Reference yield:

methyl 2-methyl-3-oxothiazoline-5-carboxylate (100241-91-6) → 3-methoxy-5-(N-methyl-N-benzylaminomethyl)isothiazole (100241-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / sodium borohydride / methanol / 3 h / 0 °C

2: 74 percent / SOCl₂ / 0.75 h / Heating

3: 85 percent / methanol / 24 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; In methanol;

upstream raw materials:

3-methoxy-5-(chloromethyl)isothiazole

benzyl-methyl-amine

5-(hydroxymethyl)-3-methoxyisothiazole

methyl 2-methyl-3-oxothiazoline-5-carboxylate

Refernces