Methyl (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenylcarbamate

Base Information

Chemical Name:Methyl (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenylcarbamate
CAS No.:122990-58-3
Molecular Formula:C₂₃H₃₀N₂O₂
Molecular Weight:366.503
Hs Code.:
DSSTox Substance ID:DTXSID00924333

Synonyms:BRN 3628816;Methyl (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenylcarbamate;Carbamic acid, (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenyl-, methyl ester;122990-58-3;DTXSID00924333;LS-49623;Methyl [2,5-dimethyl-1-(2-phenylethyl)piperidin-4-yl]phenylcarbamate

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenylcarbamate

Chemical Property:

Vapor Pressure:5.56E-09mmHg at 25°C
Boiling Point:469.3°C at 760 mmHg
Flash Point:237.6°C
Density:1.08g/cm³
XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:366.230728204
Heavy Atom Count:27
Complexity:457

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(C(CN1CCC2=CC=CC=C2)C)N(C3=CC=CC=C3)C(=O)OC

Technology Process of Methyl (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenylcarbamate

There total 4 articles about Methyl (2,5-dimethyl-1-(2-phenylethyl)-4-piperidinyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 105115-49-9
(2,5-Dimethyl-1-phenethyl-piperidin-4-yl)-phenyl-amine

: 79-22-1
methyl chloroformate

: 122990-58-3
(2,5-Dimethyl-1-phenethyl-piperidin-4-yl)-phenyl-carbamic acid methyl ester

Guidance literature:: With triethylamine; In benzene; for 7h; Ambient temperature;
DOI:10.1007/BF00758289

Reference yield:

: 29280-78-2
1-(2-phenylethyl)-2,5-dimethyl-4-piperidone

: 122990-58-3
(2,5-Dimethyl-1-phenethyl-piperidin-4-yl)-phenyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / glacial acetic acid / toluene / Heating

2: 80 percent / sodium borohydride / methanol / 0.5 h / 20 °C

3: 72 percent / triethylamine / benzene / 7 h / Ambient temperature

With sodium tetrahydroborate; acetic acid; triethylamine; In methanol; toluene; benzene;
DOI:10.1007/BF00758289

Reference yield:

: 123039-70-3
[2,5-Dimethyl-1-phenethyl-piperidin-(4E)-ylidene]-phenyl-amine

: 122990-58-3
(2,5-Dimethyl-1-phenethyl-piperidin-4-yl)-phenyl-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / sodium borohydride / methanol / 0.5 h / 20 °C

2: 72 percent / triethylamine / benzene / 7 h / Ambient temperature

With sodium tetrahydroborate; triethylamine; In methanol; benzene;
DOI:10.1007/BF00758289