2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

Base Information

Chemical Name:2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone
CAS No.:166756-95-2
Molecular Formula:C₁₈H₁₄N₂O₂
Molecular Weight:290.321
Hs Code.:

Synonyms:

Suppliers and Price of 2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

There total 7 articles about 2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77123-58-1
2-[2-(trimethylsilyl)ethynyl]benzaldehyde

: 166756-95-2
2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / MeLi / tetrahydrofuran / 2 h / Ambient temperature

2: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran; H₂O / 16 h / 25 °C

3: 82 percent / triethylamine, bis(triphenylphosphine)palladium(II) chloride, CuI / 16 h / 60 °C

4: KOH / H₂O; methanol / 5 h / 70 °C

5: oxalyl chloride, dimethylformamide / diethyl ether / 2 h

6: diethyl ether / 16 h / 25 °C

With potassium hydroxide; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; oxalyl dichloride; tetrabutyl ammonium fluoride; methyllithium; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jo00122a047

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 166756-95-2
2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / triphenylphosphine, triethylamine, palladium(II) acetate, CuI / 5 h / 80 °C

2: 74 percent / MeLi / tetrahydrofuran / 2 h / Ambient temperature

3: 70 percent / tetrabutylammonium fluoride / tetrahydrofuran; H₂O / 16 h / 25 °C

4: 82 percent / triethylamine, bis(triphenylphosphine)palladium(II) chloride, CuI / 16 h / 60 °C

5: KOH / H₂O; methanol / 5 h / 70 °C

6: oxalyl chloride, dimethylformamide / diethyl ether / 2 h

7: diethyl ether / 16 h / 25 °C

With potassium hydroxide; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; oxalyl dichloride; tetrabutyl ammonium fluoride; methyllithium; palladium diacetate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1021/jo00122a047

Reference yield:

: 153093-72-2
1-(2-ethynylphenyl)-2-phenylethanol

: 166756-95-2
2-(1-Methyl-1H-2-benzopyran-3-yl)-α-diazoacetophenone

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / triethylamine, bis(triphenylphosphine)palladium(II) chloride, CuI / 16 h / 60 °C

2: KOH / H₂O; methanol / 5 h / 70 °C

3: oxalyl chloride, dimethylformamide / diethyl ether / 2 h

4: diethyl ether / 16 h / 25 °C

With potassium hydroxide; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In methanol; diethyl ether; water;
DOI:10.1021/jo00122a047