C₁₆H₂₂O₂S

Base Information

Chemical Name:C₁₆H₂₂O₂S
CAS No.:1548669-04-0
Molecular Formula:C₁₆H₂₂O₂S
Molecular Weight:278.415
Hs Code.:

C<sub>16</sub>H<sub>22</sub>O<sub>2</sub>S

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₆H₂₂O₂S

Chemical Property:

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Technology Process of C₁₆H₂₂O₂S

There total 16 articles about C₁₆H₂₂O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4551-15-9
phenylthiotrimethylsilane

: 1548668-61-6
C₁₂H₂₀O₄

: 1548669-04-0
C₁₆H₂₂O₂S

Guidance literature:: With 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jo4025545

Reference yield:

: 183722-51-2
((2R,3S)-3-(4-methoxybenzyloxy)tetrahydro-2H-pyran-2-yl)methanol

: 1548669-04-0
C₁₆H₂₂O₂S

Guidance literature:: Multi-step reaction with 16 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 0.33 h / 0 °C

2.1: toluene / 43 h / 20 °C

3.1: nickel dichloride; sodium tetrahydroborate / methanol / 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

5.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C

6.1: dimethyl sulfoxide / 2.5 h / 60 °C

7.1: potassium hydroxide / water; ethanol / 18 h / 80 °C

8.1: triethylamine / tetrahydrofuran / 3 h / -78 - 0 °C

9.1: lithium chloride / tetrahydrofuran / 33 h / 20 °C

10.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

10.2: 4 h / -78 °C

11.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 0 - 20 °C / pH 7

12.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.75 h / 0 °C

13.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

13.2: 1 h / 110 °C

14.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -78 °C

15.1: dmap; pyridine / dichloromethane; hexane / 4 h / -78 °C

16.1: 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2 h / 0 °C

With pyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; 2,6-di-tert-butyl-pyridine; lithium hydroxide monohydrate; trimethylsilyl trifluoromethanesulfonate; 2,4,6-trichlorobenzoyl chloride; dihydrogen peroxide; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; potassium hydroxide; nickel dichloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; 13.1: |Yamaguchi Lactonization / 13.2: |Yamaguchi Lactonization;
DOI:10.1021/jo4025545

Reference yield:

: 1548667-82-8
C₁₈H₂₆O₅

: 1548669-04-0
C₁₆H₂₂O₂S

Guidance literature:: Multi-step reaction with 13 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C

3.1: dimethyl sulfoxide / 2.5 h / 60 °C

4.1: potassium hydroxide / water; ethanol / 18 h / 80 °C

5.1: triethylamine / tetrahydrofuran / 3 h / -78 - 0 °C

6.1: lithium chloride / tetrahydrofuran / 33 h / 20 °C

7.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

7.2: 4 h / -78 °C

8.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1.5 h / 0 - 20 °C / pH 7

9.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0.75 h / 0 °C

10.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 0.5 h / 0 - 20 °C

10.2: 1 h / 110 °C

11.1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / -78 °C

12.1: dmap; pyridine / dichloromethane; hexane / 4 h / -78 °C

13.1: 2,6-di-tert-butyl-pyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2 h / 0 °C

With pyridine; dmap; lithium aluminium tetrahydride; 2,6-di-tert-butyl-pyridine; lithium hydroxide monohydrate; trimethylsilyl trifluoromethanesulfonate; 2,4,6-trichlorobenzoyl chloride; dihydrogen peroxide; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; potassium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; 10.1: |Yamaguchi Lactonization / 10.2: |Yamaguchi Lactonization;
DOI:10.1021/jo4025545