Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester
• CAS No.: 191276-05-8
• Molecular Formula: C₃₀H₄₁NO₁₃
• Molecular Weight: 623.654
• Mol file: 191276-05-8.mol

Synonyms:

Chemical Property of Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester

There total 7 articles about Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(2-bromomethyl-phenyl)-(tetra-O-acetyl-β-D-galactopyranoside) (191276-03-6) + 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol (122194-06-3) → Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester (191276-05-8)

Guidance literature:

at 45 ℃;

DOI:10.1016/S0960-894X(97)00189-3

Reference yield:

(3aS,4S,6R,6aS)-6-Benzyloxy-2,2,6-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carbaldehyde → Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester (191276-05-8)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / methanol

2: pyridine / CH₂Cl₂

3: NaN₃ / dimethylformamide / 0 °C

4: 74 percent / ammonium formate / 10percent Pd-C / 60 °C

5: 26 percent / 45 °C

With pyridine; sodium tetrahydroborate; sodium azide; ammonium formate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00189-3

Reference yield:

(3aS,4R,6R,6aS)-4-Benzyloxy-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2,4-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxole (191275-96-4) → Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[2-((3aR,4S,7R,7aS)-7-hydroxy-2,2,4-trimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyridin-5-ylmethyl)-phenoxy]-tetrahydro-pyran-3-yl ester (191276-05-8)

Guidance literature:

Multi-step reaction with 6 steps

1: periodic acid / tetrahydrofuran; H₂O

2: NaBH₄ / methanol

3: pyridine / CH₂Cl₂

4: NaN₃ / dimethylformamide / 0 °C

5: 74 percent / ammonium formate / 10percent Pd-C / 60 °C

6: 26 percent / 45 °C

With pyridine; sodium tetrahydroborate; sodium azide; ammonium formate; periodic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00189-3

upstream raw materials:

(2-bromomethyl-phenyl)-(tetra-O-acetyl-β-D-galactopyranoside)

1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol

ortho-cresol

(3aS,4R,6R,6aS)-6-Azidomethyl-4-benzyloxy-2,2,4-trimethyl-tetrahydro-furo[3,4-d][1,3]dioxole