(S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Base Information

• Chemical Name: (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate
• CAS No.: 1429501-99-4
• Molecular Formula: C₂HF₃O₂*C₁₇H₁₈ClNO
• Molecular Weight: 401.813
• Mol file: 1429501-99-4.mol

Synonyms:

Chemical Property of (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate

There total 5 articles about (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H18ClNO (1204672-59-2) + trifluoroacetic acid (76-05-1) → (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate (1429501-99-4)

Guidance literature:

In water; acetonitrile;

DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate (199174-24-8) → (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate (1429501-99-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 0 °C

2.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 3 h / 70 °C

4.1: hydrogenchloride / ethanol

5.1: water; acetonitrile

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydride; sodium hydrogencarbonate; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester (191348-04-6) → (S)-3-[(R)-(4-chlorophenoxy)phenylmethyl]pyrrolidine trifluoroacetate (1429501-99-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 3 h / 70 °C

3.1: hydrogenchloride / ethanol

4.1: water; acetonitrile

With hydrogenchloride; sodium hydride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2012.12.061

upstream raw materials:

C₁₇H₁₈ClNO

trifluoroacetic acid

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester

Refernces