Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

Base Information

Chemical Name:Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester
CAS No.:174399-96-3
Molecular Formula:C₂₃H₂₅N₂O₆PS
Molecular Weight:488.501
Hs Code.:

Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

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Chemical Property of Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

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Technology Process of Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

There total 4 articles about Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 174399-98-5
thioacetic acid S-[2-(diphenyl-phosphinoyloxymethoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

: 174399-96-3
Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

Guidance literature:: With ammonia; at 0 ℃;
DOI:10.1016/S0960-894X(98)00741-0

Reference yield:

: 3’-deoxy-5’-O-dimethoxytrityl-3’-(acetylthio)thymidine

: 174399-96-3
Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / MeSO₃H / methanol; CH₂Cl₂

2: 62 percent / Bz₂O₂

3: 90 percent / N-iodosuccinimide

4: methanolic NH₃ / 0 °C

With N-iodo-succinimide; methanesulfonic acid; ammonia; dibenzoyl peroxide; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00741-0

Reference yield:

: 115913-88-7
3'-(acetylthio)-2',3'-dideoxythymidine

: 174399-96-3
Diphenyl-phosphinic acid (2R,3S,5R)-3-mercapto-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Bz₂O₂

2: 90 percent / N-iodosuccinimide

3: methanolic NH₃ / 0 °C

With N-iodo-succinimide; ammonia; dibenzoyl peroxide;
DOI:10.1016/S0960-894X(98)00741-0