Technology Process of 10-(3-hydroxyphenyl)dec-2-yn-1-ol
There total 19 articles about 10-(3-hydroxyphenyl)dec-2-yn-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) Mg / 1.) THF, 2.) THF, 24 h
2: 81 percent / toluene-4-sulphonic acid / ethanol / 24 h / Heating
3: 1.) KOH, 2.) H2, H2SO4 / 2.) 10percent Pd/C / 1.) ethanol, 1 h, reflux, 2.) ethanol, r.t.
4: 4.31 g / PBr3 / CHCl3 / 4 h / 0 °C
5: 1.) LiNH2, Fe(NO3)3 / 1.) liq. NH3, THF, HMPA, 2.) liq. NH3, THF, HMPA, 40 deg C, 24 h
6: p-TsOH / ethanol / 3 h / Heating
With
potassium hydroxide; lithium amide; sulfuric acid; hydrogen; phosphorus tribromide; toluene-4-sulfonic acid; magnesium; ferric nitrate;
palladium on activated charcoal;
In
ethanol; chloroform;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 66 percent / conc. HCl, CuCl / toluene / 24 h / 100 °C
2: 84 percent / K2CO3 / benzene / 24 h / Heating
3: 2.) H2
4: 91 percent / BBr3 / CH2Cl2 / 1.) -80 deg C, 3 d, 2.) 72 h
5: 1.) LiNH2, Fe(NO3)3 / 1.) liq. NH3, THF, HMPA, 2.) liq. NH3, THF, HMPA, 40 deg C, 24 h
6: p-TsOH / ethanol / 3 h / Heating
With
hydrogenchloride; lithium amide; hydrogen; boron tribromide; potassium carbonate; toluene-4-sulfonic acid; ferric nitrate; copper(l) chloride;
In
ethanol; dichloromethane; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / K2CO3 / benzene / 24 h / Heating
2: 2.) H2
3: 91 percent / BBr3 / CH2Cl2 / 1.) -80 deg C, 3 d, 2.) 72 h
4: 1.) LiNH2, Fe(NO3)3 / 1.) liq. NH3, THF, HMPA, 2.) liq. NH3, THF, HMPA, 40 deg C, 24 h
5: p-TsOH / ethanol / 3 h / Heating
With
lithium amide; hydrogen; boron tribromide; potassium carbonate; toluene-4-sulfonic acid; ferric nitrate;
In
ethanol; dichloromethane; benzene;
