Technology Process of (4S)-3-<(2R)-2-(N-Benzylamino)propionyl>-4-(tert-butoxymethyl)-1-methyl-2-oxoimidazolidine
There total 6 articles about (4S)-3-<(2R)-2-(N-Benzylamino)propionyl>-4-(tert-butoxymethyl)-1-methyl-2-oxoimidazolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 73 percent / 4 N aq. HCl / dioxane / 6 h / Ambient temperature
2: BMS / tetrahydrofuran / 1.) r.t., 2 h, 2.) reflux, 2 h
3: H2SO4 / CH2Cl2 / Ambient temperature
4: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
5: 70 percent / t-BuOK / tetrahydrofuran / 1.) -50 deg C, 20 min, 2.) -30 deg C, 30 min
6: K2CO3 / hexamethylphosphoric acid triamide / 14 h / 25 °C
With
hydrogenchloride; dimethylsulfide borane complex; sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jo00126a029
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2SO4 / CH2Cl2 / Ambient temperature
2: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
3: 70 percent / t-BuOK / tetrahydrofuran / 1.) -50 deg C, 20 min, 2.) -30 deg C, 30 min
4: K2CO3 / hexamethylphosphoric acid triamide / 14 h / 25 °C
With
sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jo00126a029
- Guidance literature:
-
Multi-step reaction with 5 steps
1: BMS / tetrahydrofuran / 1.) r.t., 2 h, 2.) reflux, 2 h
2: H2SO4 / CH2Cl2 / Ambient temperature
3: 93 percent / H2 / 10percent Pd/C / methanol / 3 h / Ambient temperature
4: 70 percent / t-BuOK / tetrahydrofuran / 1.) -50 deg C, 20 min, 2.) -30 deg C, 30 min
5: K2CO3 / hexamethylphosphoric acid triamide / 14 h / 25 °C
With
dimethylsulfide borane complex; sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jo00126a029
