(1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

Base Information

Chemical Name:(1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid
CAS No.:402959-45-9
Molecular Formula:C₂₈H₄₁N₅O₅
Molecular Weight:527.664
Hs Code.:

(1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

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Chemical Property of (1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

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Technology Process of (1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

There total 6 articles about (1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 402959-45-9
(1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HOBt; EDCl

2: aq. NaOH / methanol

3: HOAt; DCC / CH₂Cl₂; tetrahydrofuran

4: aq. NaOH

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.07.007

Reference yield:

: 37736-82-6
(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

: 402959-45-9
(1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: HOBt; EDCl / tetrahydrofuran

2: HCl / dioxane; tetrahydrofuran

3: HOBt; EDCl

4: aq. NaOH / methanol

5: HOAt; DCC / CH₂Cl₂; tetrahydrofuran

6: aq. NaOH

With hydrogenchloride; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.07.007

Reference yield:

: 402959-42-6
(S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyric acid methyl ester

: 402959-45-9
(1S,3aR,6aS)-2-((S)-2-{(S)-3-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-propionylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / methanol

2: HOAt; DCC / CH₂Cl₂; tetrahydrofuran

3: aq. NaOH

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.07.007