Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

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Chemical Name:Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester
CAS No.:110828-48-3
Molecular Formula:C₅₀H₅₃NO₆Si
Molecular Weight:792.059
Hs Code.:

Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

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Chemical Property of Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

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Technology Process of Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

There total 14 articles about Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 39746-01-5,61348-03-6,61348-04-7,98673-94-0,118711-80-1
Benzoic acid (3aR,5R,6aS)-4-formyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

: 110828-45-0
{4-[2-(tert-Butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-2-oxo-butyl}-phosphonic acid dimethyl ester

: 110828-48-3
Benzoic acid (3aR,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Guidance literature:: With sodium hydride;
DOI:10.1016/S0040-4039(00)95644-2

Reference yield:

: 882-06-4
4-nitro-trans-cinnamic acid

: 110828-48-3
Benzoic acid (3aR,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / H₂ / Pd-C

2: 90 percent / HCl, NaNO₂, NaN₃

3: 56 percent / TFA

4: 65 percent / 6 M HCl

5: 70 percent / pyridine

6: 90 percent / imidazole

7: 99 percent / n-BuLi

8: 71 percent / NaH

With pyridine; 1H-imidazole; hydrogenchloride; n-butyllithium; sodium azide; hydrogen; sodium hydride; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal;
DOI:10.1016/S0040-4039(00)95644-2

Reference yield:

: 76-83-5
trityl chloride

: 110828-48-3
Benzoic acid (3aR,4R,5R,6aS)-4-{(E)-5-[2-(tert-butyl-dimethyl-silanyloxy)-4-(trityl-amino)-phenyl]-3-oxo-pent-1-enyl}-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: imidazole

3: 1) n-Buli

4: 1) NaH

With pyridine; 1H-imidazole; n-butyllithium; sodium hydride;
DOI:10.1021/jm00121a046