Technology Process of (3aS,4S,6R,6aR)-4-Diazomethyl-2,2-dimethyl-6-trityloxymethyl-tetrahydro-cyclopenta[1,3]dioxole
There total 12 articles about (3aS,4S,6R,6aR)-4-Diazomethyl-2,2-dimethyl-6-trityloxymethyl-tetrahydro-cyclopenta[1,3]dioxole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NH3 / methanol / 20 °C
2: 69.81 g / Et3N; DMAP / acetonitrile / 4 h / 20 °C
3: BH3 / tetrahydrofuran / Heating
4: 35.95 g / Et3N; DMAP / acetonitrile / 3.5 h
5: N2O4; NaOAc / CCl4; acetic acid / 2 h / 0 °C
6: KOH / diethyl ether; H2O / 2 h / 0 °C
With
dmap; potassium hydroxide; borane; ammonia; sodium acetate; dinitrogen tetraoxide; triethylamine;
In
tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; water; acetic acid; acetonitrile;
1: Ring cleavage / 2: Etherification / 3: Reduction / 4: Acetylation / 5: Nitrosation / 6: Elimination;
DOI:10.1080/15257779908043088
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Et3N; DMAP / 1,2-dichloro-ethane / 4 h / 60 °C
2: 149.25 g / K2CO3 / methanol / 5 h
3: pyridinium chlorochromate; sodium acetate / CH2Cl2 / 4 h / 20 °C
4: hydroxylammonium chloride / methanol / 1 h / Heating
5: LiAlH4 / diethyl ether / 4 h
6: 35.95 g / Et3N; DMAP / acetonitrile / 3.5 h
7: N2O4; NaOAc / CCl4; acetic acid / 2 h / 0 °C
8: KOH / diethyl ether; H2O / 2 h / 0 °C
With
dmap; potassium hydroxide; lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; dinitrogen tetraoxide; potassium carbonate; triethylamine; pyridinium chlorochromate;
In
methanol; tetrachloromethane; diethyl ether; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; acetonitrile;
1: Etherification / 2: deacylation / 3: Oxidation / 4: Condensation / 5: Reduction / 6: Acetylation / 7: Nitrosation / 8: Elimination;
DOI:10.1080/15257779908043088
