(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

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Chemical Name:(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide
CAS No.:78768-55-5
Molecular Formula:C₂₈H₃₆N₆O₆S
Molecular Weight:584.696
Hs Code.:

(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

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Chemical Property of (S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

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Technology Process of (S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

There total 4 articles about (S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83-07-8
4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

: 78768-55-5
(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / dicyclohexylcarbodiimide / dioxane; dimethylformamide / 1.) 0 deg C, 27 h; 2.) room temperature, 24 h.

2: 60 percent / hydrazine hydrate / ethanol / 1.) reflux, 2 h; 2.) room temperature, 24 h.

3: 1.) NaNO₂, 5N HCl / 1.) acetic acid, water, -5 deg C, 5 min; 2.) ethyl acetate, 0 deg C, 24 h, room temperature, 24 h.

With hydrogenchloride; hydrazine hydrate; dicyclohexyl-carbodiimide; sodium nitrite; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570180119

Reference yield:

: 78768-40-8
(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-butyramide

: 78768-55-5
(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / hydrazine hydrate / ethanol / 1.) reflux, 2 h; 2.) room temperature, 24 h.

2: 1.) NaNO₂, 5N HCl / 1.) acetic acid, water, -5 deg C, 5 min; 2.) ethyl acetate, 0 deg C, 24 h, room temperature, 24 h.

With hydrogenchloride; hydrazine hydrate; sodium nitrite; In ethanol;
DOI:10.1002/jhet.5570180119

Reference yield:

: 6306-54-3
N-phthaloyl L-valine

: 78768-55-5
(S)-N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-2-{2-[(S)-2-(toluene-4-sulfonylamino)-propionylamino]-acetylamino}-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / dicyclohexylcarbodiimide / dioxane; dimethylformamide / 1.) 0 deg C, 27 h; 2.) room temperature, 24 h.

2: 60 percent / hydrazine hydrate / ethanol / 1.) reflux, 2 h; 2.) room temperature, 24 h.

3: 1.) NaNO₂, 5N HCl / 1.) acetic acid, water, -5 deg C, 5 min; 2.) ethyl acetate, 0 deg C, 24 h, room temperature, 24 h.

With hydrogenchloride; hydrazine hydrate; dicyclohexyl-carbodiimide; sodium nitrite; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570180119