Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-

Base Information

Chemical Name:Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-
CAS No.:138249-74-8
Molecular Formula:C8H11F3O2
Molecular Weight:196.169
Hs Code.:
DSSTox Substance ID:DTXSID90449227
Nikkaji Number:J1.022.669D
Mol file:138249-74-8.mol

Synonyms:Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-;138249-74-8;SCHEMBL9752229;DTXSID90449227;QYKJWBGZUCBSKG-UHFFFAOYSA-N;2-(1-Hydroxy-2,2,2-trifluoroethyl)cyclohexanone

Suppliers and Price of Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:196.07111408
Heavy Atom Count:13
Complexity:200

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(=O)C(C1)C(C(F)(F)F)O

Technology Process of Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)-

There total 5 articles about Cyclohexanone, 2-(2,2,2-trifluoro-1-hydroxyethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 188429-64-3
2,2,2-trifluoro-N,N,N',N'-tetramethylethane-1,1-diamine

: 138249-74-8
2-(2,2,2-trifluoro-1-hydroxyethyl)cyclohexanone

Guidance literature:: With hydrogenchloride; In neat (no solvent); at 80 ℃; for 18h;
DOI:10.1016/S0040-4039(98)02106-6

Reference yield: 32.0%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 433-27-2
ethyl trifluoroacetaldehyde hemiacetal

: 138249-74-8
2-(2,2,2-trifluoro-1-hydroxyethyl)cyclohexanone

: 141023-10-1
2,6-Bis(3,3,3-trifluoroethylidene)cyclohexane

Guidance literature:: With zinc(II) iodide; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)91620-4

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 433-27-2
ethyl trifluoroacetaldehyde hemiacetal

: anti-2-(1'-hydroxy-2',2',2'-trifluoroethyl)cyclohexanone

: 138249-74-8
2-(2,2,2-trifluoro-1-hydroxyethyl)cyclohexanone

Guidance literature:: With 5-[(2S)-pyrrolidine-2-yl]-1H-tetrazole; In 1,2-dichloro-ethane; at 40 ℃; for 3h; optical yield given as %ee; stereoselective reaction;
DOI:10.1021/jo200020z