Technology Process of (E,3S,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester
There total 8 articles about (E,3S,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 6 h / Heating
2: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 3 deg C, 2.) THF, hexane, -40 deg C
3: NaOMe / Ambient temperature
4: 1.) n-butyllithium, diisopropylamine / 1.) cyclohexane, hexane, 3 deg C, 2.) cyclohexane, hexane, THF, 3 deg C
5: 1.) methoxydiethylborane, 2.) sodium borohydride / 1.) THF, methanol, -75 deg C, 2.) THF, methanol, -75 deg C,
With
sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; sodium methylate; lithium dicyclohexylamide; diisopropylamine;
In
tetrahydrofuran;
DOI:10.1021/jm00075a020
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / MnO2 / CH2Cl2 / 1 h / Ambient temperature
2: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 3 deg C, 2.) THF, hexane, -40 deg C
3: NaOMe / Ambient temperature
4: 1.) n-butyllithium, diisopropylamine / 1.) cyclohexane, hexane, 3 deg C, 2.) cyclohexane, hexane, THF, 3 deg C
5: 1.) methoxydiethylborane, 2.) sodium borohydride / 1.) THF, methanol, -75 deg C, 2.) THF, methanol, -75 deg C,
With
manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; sodium methylate; lithium dicyclohexylamide; diisopropylamine;
In
dichloromethane;
DOI:10.1021/jm00075a020
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 81 percent / DIBAL-H / CH2Cl2 / 2 h / -78 °C
2: 75 percent / MnO2 / CH2Cl2 / 1 h / Ambient temperature
3: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 3 deg C, 2.) THF, hexane, -40 deg C
4: NaOMe / Ambient temperature
5: 1.) n-butyllithium, diisopropylamine / 1.) cyclohexane, hexane, 3 deg C, 2.) cyclohexane, hexane, THF, 3 deg C
6: 1.) methoxydiethylborane, 2.) sodium borohydride / 1.) THF, methanol, -75 deg C, 2.) THF, methanol, -75 deg C,
With
manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; sodium methylate; diisobutylaluminium hydride; lithium dicyclohexylamide; diisopropylamine;
In
dichloromethane;
DOI:10.1021/jm00075a020
