Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

• Chemical Name: Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• CAS No.: 170999-47-0
• Molecular Formula: C₃₇H₃₇N₆O₈P
• Molecular Weight: 724.71
• Mol file: 170999-47-0.mol

Synonyms:

Chemical Property of Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosphorotriimidazolide (16062-77-4) + 3'-O-(4,4'-dimethoxytrityl)thymidine (76054-81-4) → Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (170999-47-0)

Guidance literature:

In pyridine; for 2h; Ambient temperature;

Reference yield:

Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (170999-47-0) → 3'-O-dimethoxytritylthymidine phosphorodifluoridate

Guidance literature:

With benzoyl fluoride; In pyridine; dichloromethane; for 2h; Yield given; Ambient temperature;

Reference yield:

Di-imidazol-1-yl-phosphinic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (170999-47-0) → Toluene-4-sulfonic acid (4aR,6R,7aS)-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl ester (170999-49-2)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 1 h / Ambient temperature

2: Cl₂CHCO₂H / CH₂Cl₂ / 0.02 h

3: N-methylimidazole / acetonitrile / 1 h / Ambient temperature

With 1-methyl-1H-imidazole; dichloro-acetic acid; In dichloromethane; acetonitrile;

upstream raw materials:

phosphorotriimidazolide

3'-O-(4,4'-dimethoxytrityl)thymidine

Downstream raw materials:

Toluene-4-sulfonic acid (4aR,6R,7aS)-6-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl ester

C₂₄H₂₇N₂O₁₂PS₂