Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester

Base Information

• Chemical Name: Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester
• CAS No.: 165392-08-5
• Molecular Formula: C₅₀H₈₆N₂O₁₀
• Molecular Weight: 875.24
• Mol file: 165392-08-5.mol

Synonyms:

Chemical Property of Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester

There total 3 articles about Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

n-tetradecanoic acid (544-63-8) + (S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoic acid (R)-2,3-dihydroxy-propyl ester → Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester (165392-08-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 6h;

DOI:10.1246/cl.1995.473

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester (165392-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / 1,3-dicylohexylcarbodiimide, 4-dimethylaminopyridine / CH₂Cl₂ / 6 h

2: 80 percent / 0.01 N aq. HCl / methanol / 17 h

3: 65 percent / 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH₂Cl₂ / 6 h

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1246/cl.1995.473

Reference yield:

(S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoic acid (R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester → Tetradecanoic acid (R)-2-((S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyloxy)-1-tetradecanoyloxymethyl-ethyl ester (165392-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 0.01 N aq. HCl / methanol / 17 h

2: 65 percent / 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH₂Cl₂ / 6 h

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1246/cl.1995.473

upstream raw materials:

n-tetradecanoic acid

Z-Lys(Boc)-OH