3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)-

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)-
CAS No.:138279-11-5
Molecular Formula:C24H30N2O9
Molecular Weight:490.51
Hs Code.:
Mol file:138279-11-5.mol

3,5-Pyridinedicarboxylic acid,
1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-,
(2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)-

Synonyms:

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)-

Chemical Property:

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Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)-

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-, (2,2-dimethyl-1-oxopropoxy)methyl methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 138279-10-4
(S)-1-Methoxymethyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid mono-(2,2-dimethyl-propionyloxymethyl) ester

: 138279-11-5
(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: In diethyl ether; dichloromethane; at 0 ℃; for 1h;
DOI:10.1248/cpb.45.863

Reference yield:

: 123973-70-6
1,4-dihydro-2,6-dimethyl-1-methoxymethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid

: 138279-11-5
(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 18 h

2: lipase PS, H₂O / diisopropyl ether / 72 h / Ambient temperature

3: 94 percent / diethyl ether; CH₂Cl₂ / 1 h / 0 °C

With Lipase PS; water; sodium hydride; In diethyl ether; dichloromethane; di-isopropyl ether;
DOI:10.1248/cpb.45.863

Reference yield:

: 138299-10-2
bis(pivaloyloxymethyl) 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

: 138279-11-5
(S)-(+)-methyl pivaloyloxymethyl 1,4-dihydro-1-(methoxymethyl)-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lipase PS, H₂O / diisopropyl ether / 72 h / Ambient temperature

2: 94 percent / diethyl ether; CH₂Cl₂ / 1 h / 0 °C

With Lipase PS; water; In diethyl ether; dichloromethane; di-isopropyl ether;
DOI:10.1248/cpb.45.863