{4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester

Base Information

• Chemical Name: {4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester
• CAS No.: 186706-99-0
• Molecular Formula: C₄₈H₆₆O₁₃P₄
• Molecular Weight: 974.939

Synonyms:

Chemical Property of {4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester

There total 2 articles about {4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[bis(ethyloxy)phosphoryl]methyl 4-chlorobenzenesulfonate (35449-95-7) + [4-tert-Butyl-2-(12-tert-butyl-1,6-dihydroxy-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl)-6-methyl-benzyl]-phosphonic acid dimethyl ester (186706-97-8) → {4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester (186706-99-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; In benzene; at 44 ℃; for 18h; Yield given;

DOI:10.1039/P19960002889

Reference yield:

Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester (186706-95-6) → {4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester (186706-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 0.02 h

2: NaH, HMPA / benzene / 18 h / 44 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium hydride; In methanol; benzene;

DOI:10.1039/P19960002889

Reference yield:

{4-tert-Butyl-2-[12-tert-butyl-1,6-bis-(diethoxy-phosphorylmethoxy)-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ5-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl]-6-methyl-benzyl}-phosphonic acid dimethyl ester (186706-99-0) → {4-tert-Butyl-2-[6-(5-tert-butyl-2,3-dimethyl-phenyl)-5-hydroxy-5-oxo-3,7-bis-phosphonomethoxy-5H-5λ5-dibenzophosphol-4-yl]-6-methyl-benzyl}-phosphonic acid

Guidance literature:

Multi-step reaction with 2 steps

1: iodotrimethylsilane / CHCl₃ / 25 h

2: 1.) Zn, Cu, 2.) H₂ / 2.) 10percent Pd/C / 1.) MeOH, overnight, 2.) MeOH, 1 atm, overnight

With trimethylsilyl iodide; hydrogen; copper; zinc; palladium on activated charcoal; In chloroform;

DOI:10.1039/P19960002889

upstream raw materials:

[bis(ethyloxy)phosphoryl]methyl 4-chlorobenzenesulfonate

[4-tert-Butyl-2-(12-tert-butyl-1,6-dihydroxy-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-7-yl)-6-methyl-benzyl]-phosphonic acid dimethyl ester

Acetic acid 1-acetoxy-12-tert-butyl-7-[5-tert-butyl-2-(dimethoxy-phosphorylmethyl)-3-methyl-phenyl]-10-methyl-7b-oxo-7bH,9H-8-oxa-7bλ⁵-phospha-benzo[6,7]cyclohepta[1,2,3-jk]fluoren-6-yl ester

Downstream raw materials:

{4-tert-Butyl-2-[6-(5-tert-butyl-2-iodomethyl-3-methyl-phenyl)-5-hydroxy-5-oxo-3,7-bis-phosphonomethoxy-5H-5λ⁵-dibenzophosphol-4-yl]-6-methyl-benzyl}-phosphonic acid

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