Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide

Base Information

• Chemical Name: Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide
• CAS No.: 191860-99-8
• Molecular Formula: C₁₅H₉ClOS₂
• Molecular Weight: 304.821
• Mol file: 191860-99-8.mol

Synonyms:

Chemical Property of Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide

There total 2 articles about Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(4-Chloro-thiobenzoylsulfanyl)-phenyl-acetic acid (191860-98-7) → Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide (191860-99-8)

Guidance literature:

With acetic anhydride; triethylamine; 1.) 8-10 deg C, 2 h, 2.) r.t., overnight;

DOI:10.1016/S0022-1139(96)03575-0

Reference yield:

dithio-4-chlorobenzoic acid (2168-82-3) → Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide (191860-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. Na₂CO₃ / 1.) 0 deg C, 4 h, 2.) 4 deg C, overnight

2: 55 percent / Ac₂O, Et₃N / 1.) 8-10 deg C, 2 h, 2.) r.t., overnight

With acetic anhydride; sodium carbonate; triethylamine;

DOI:10.1016/S0022-1139(96)03575-0

Reference yield:

1-nitro-4-(3,3,3-trifluoroprop-1-yn-1-yl)benzene (1983-22-8) + Anhydro-4-hydroxy-2-(4-chlorophenyl)-5-phenyl-1,3-dithiolium hydroxide (191860-99-8) → 2-(4-Chloro-phenyl)-3-(4-nitro-phenyl)-5-phenyl-4-trifluoromethyl-thiophene + 2-(4-Chloro-phenyl)-4-(4-nitro-phenyl)-5-phenyl-3-trifluoromethyl-thiophene

Guidance literature:

In xylene; at 120 ℃; for 20h; Yield given. Yields of byproduct given;

DOI:10.1016/S0022-1139(96)03575-0

upstream raw materials:

(4-Chloro-thiobenzoylsulfanyl)-phenyl-acetic acid

dithio-4-chlorobenzoic acid