2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

Base Information

• Chemical Name: 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine
• CAS No.: 356065-62-8
• Molecular Formula: C₄₈H₆₂FN₅O₁₆Si₂
• Molecular Weight: 1040.21

Synonyms:

Chemical Property of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

There total 1 articles about 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N4-<2-(4-nitrophenyl)ethoxycarbonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine (155834-43-8) + 3-Fluoro-4-[2-(4-nitrophenyl)ethoxycarbonyloxy]benzyl vinyl ether (213548-00-6) → 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine (356065-62-8)

Guidance literature:

DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

Reference yield: 90.0%

2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine (356065-62-8) → 2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (356065-71-9)

Guidance literature:

DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

Reference yield:

2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine (356065-62-8) → 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (356065-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / pyridine / toluene / 20 °C

With pyridine; In toluene;

DOI:10.1002/1522-2675(20010516)84:5<1066::AID-HLCA1066>3.0.CO;2-H

upstream raw materials:

N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

3-Fluoro-4-[2-(4-nitrophenyl)ethoxycarbonyloxy]benzyl vinyl ether

Downstream raw materials:

2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-{1-{{3-fluoro-4-{{[2-(4-nitrophenyl)ethoxy]carbonyl}oxy}benzyl}oxy}ethyl}-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

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