N^α-(9-fluorenylmethyloxycarbonyl)-N^ε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester

Base Information

• Chemical Name: N^α-(9-fluorenylmethyloxycarbonyl)-N^ε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester
• CAS No.: 896460-84-7
• Molecular Formula: C₄₃H₄₉N₃O₇S₂
• Molecular Weight: 784.01
• Mol file: 896460-84-7.mol

Synonyms:

Chemical Property of N^α-(9-fluorenylmethyloxycarbonyl)-N^ε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(9-fluorenylmethyloxycarbonyl)-N^ε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester

There total 1 articles about N^α-(9-fluorenylmethyloxycarbonyl)-N^ε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-(9-fluorenylmethyloxycarbonyl)-Nε-(2-phenyldisulfanylethyloxycarbonyl)-L-lysine (896460-81-4) + L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) → Nα-(9-fluorenylmethyloxycarbonyl)-Nε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester (896460-84-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.200501538

Reference yield:

Nα-(9-fluorenylmethyloxycarbonyl)-Nε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester (896460-84-7) → Nα-(9-fluorenylmethyloxycarbonyl)-Nε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/chem.200501538

Reference yield:

Nα-(9-fluorenylmethyloxycarbonyl)-Nε-(2-(phenyldisulfanyl)ethyloxycarbonyl)-L-lysyl-L-phenylalanine tert-butyl ester (896460-84-7) → [Nε-(2-(phenyldisulfanyl)ethyloxycarbonyl)]-L-lysyl-L-phenylalanine

Guidance literature:

Multi-step reaction with 2 steps

1: TFA; H₂O / CH₂Cl₂ / 2 h / 20 °C

2: Et₂NH / CH₂Cl₂ / 20 °C

With water; diethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1002/chem.200501538

upstream raw materials:

N^α-(9-fluorenylmethyloxycarbonyl)-N^ε-(2-phenyldisulfanylethyloxycarbonyl)-L-lysine

L-phenylalanine tert-butyl ester hydrochloride