(2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Base Information

• Chemical Name: (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
• CAS No.: 79827-21-7
• Molecular Formula: C₂₈H₃₂N₂O₁₀
• Molecular Weight: 556.569

Synonyms:

Chemical Property of (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

There total 3 articles about (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2R,3R)-3-[3-(2-Benzyloxycarbonyl-acetyl)-4-methoxy-phenoxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (79816-25-4) → (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (79827-21-7)

Guidance literature:

Reference yield:

3-benzyloxy-3-oxo-propanoic acid magnesium salt (79816-35-6) → (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (79827-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent

2: 91 percent

Reference yield:

(2R,3R)-3-(3-Carboxy-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (79816-24-3) → (2R,3R)-3-(3-{2-Benzyloxycarbonyl-2-[(Z)-hydroxyimino]-acetyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (79827-21-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent

2: 91 percent

upstream raw materials:

(2R,3R)-3-[3-(2-Benzyloxycarbonyl-acetyl)-4-methoxy-phenoxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

3-benzyloxy-3-oxo-propanoic acid magnesium salt

(2R,3R)-3-(3-Carboxy-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Downstream raw materials:

(2R,3R)-3-[3-(2-Amino-acetyl)-4-methoxy-phenoxy]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(2S,3S)-3-(3-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-1-hydroxy-ethyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(2S,3S)-3-(3-{(R)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-1-hydroxy-ethyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(2R,3R)-3-(3-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-1-hydroxy-ethyl}-4-methoxy-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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