1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole

Base Information

• Chemical Name: 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole
• CAS No.: 74658-74-5
• Molecular Formula: C₂₂H₁₉NO₃
• Molecular Weight: 345.398
• Mol file: 74658-74-5.mol

Synonyms:

Chemical Property of 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole

There total 3 articles about 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-oxo-2-<(+)-α-methylbenzyl>-3-hydroxy-3-phenylisoindole (74658-72-3,74658-73-4) → 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole (74658-74-5,74658-75-6)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; In dichloromethane; Ambient temperature;

DOI:10.1021/ja00537a033

Reference yield:

2-Benzoylbenzoic acid (85-52-9) → 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole (74658-74-5,74658-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) thionyl chloride, 2.) pyridine / 1) reflux, 2) benzene, 12 - 24 h, room temperature

2: 89 percent / H₂O₂, H₂SO₄ / CH₂Cl₂ / Ambient temperature

With pyridine; thionyl chloride; sulfuric acid; dihydrogen peroxide; In dichloromethane;

DOI:10.1021/ja00537a033

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → 1-oxo-2-<(+)-α-methylbenzyl>-3-hydroperoxy-3-phenylisoindole (74658-74-5,74658-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) thionyl chloride, 2.) pyridine / 1) reflux, 2) benzene, 12 - 24 h, room temperature

2: 89 percent / H₂O₂, H₂SO₄ / CH₂Cl₂ / Ambient temperature

With pyridine; thionyl chloride; sulfuric acid; dihydrogen peroxide; In dichloromethane;

DOI:10.1021/ja00537a033

upstream raw materials:

1-oxo-2-<(+)-α-methylbenzyl>-3-hydroxy-3-phenylisoindole

2-Benzoylbenzoic acid

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

1-oxo-2-<(+)-α-methylbenzyl>-3-hydroxy-3-phenylisoindole