Technology Process of 2-methoxycarbonyl-4-phenylhexa-2,4-dienylamine p-toluenesulphonate
There total 5 articles about 2-methoxycarbonyl-4-phenylhexa-2,4-dienylamine p-toluenesulphonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.) sodium borohydride / 1.) CCl4, 78-80 deg C, 12 d, 2.) methanol, 10 min
2: 78 percent / trifluoroacetic acid
3: 1.) N-methylmorpholine, diphenylphosphinic chloride, 2.) tetramethylguanidinium azide / 1.) -23 deg C, CH2Cl2, 0,5 h, 2.) CH2Cl2, 0.5 h -> 0 deg C, 2 h
4: benzene / 1.7 h / 65 - 70 °C
5: 71 percent / diethyl ether / Ambient temperature
With
4-methyl-morpholine; sodium tetrahydroborate; tetramethylguanidinum azide; trifluoroacetic acid; Diphenylphosphinic chloride;
In
diethyl ether; benzene;
DOI:10.1016/0040-4020(89)80052-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 41 percent / sodium acetate / ethanol; H2O / 1 h, r.t., 4 h, reflux, cooled overnight
2: 2.) sodium borohydride / 1.) CCl4, 78-80 deg C, 12 d, 2.) methanol, 10 min
3: 78 percent / trifluoroacetic acid
4: 1.) N-methylmorpholine, diphenylphosphinic chloride, 2.) tetramethylguanidinium azide / 1.) -23 deg C, CH2Cl2, 0,5 h, 2.) CH2Cl2, 0.5 h -> 0 deg C, 2 h
5: benzene / 1.7 h / 65 - 70 °C
6: 71 percent / diethyl ether / Ambient temperature
With
4-methyl-morpholine; sodium tetrahydroborate; sodium acetate; tetramethylguanidinum azide; trifluoroacetic acid; Diphenylphosphinic chloride;
In
diethyl ether; ethanol; water; benzene;
DOI:10.1016/0040-4020(89)80052-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) N-methylmorpholine, diphenylphosphinic chloride, 2.) tetramethylguanidinium azide / 1.) -23 deg C, CH2Cl2, 0,5 h, 2.) CH2Cl2, 0.5 h -> 0 deg C, 2 h
2: benzene / 1.7 h / 65 - 70 °C
3: 71 percent / diethyl ether / Ambient temperature
With
4-methyl-morpholine; tetramethylguanidinum azide; Diphenylphosphinic chloride;
In
diethyl ether; benzene;
DOI:10.1016/0040-4020(89)80052-3
