C₂₇H₃₄FN₅O₃*ClH

Base Information

Chemical Name:C₂₇H₃₄FN₅O₃*ClH
CAS No.:1220514-58-8
Molecular Formula:C₂₇H₃₄FN₅O₃*ClH
Molecular Weight:532.058
Hs Code.:

C<sub>27</sub>H<sub>34</sub>FN<sub>5</sub>O<sub>3</sub>*ClH

Synonyms:

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Chemical Property of C₂₇H₃₄FN₅O₃*ClH

Chemical Property:

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Technology Process of C₂₇H₃₄FN₅O₃*ClH

There total 18 articles about C₂₇H₃₄FN₅O₃*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1220514-62-4
(S)-3-tert-butoxycfarbonylamino-3-(3-fluorophenyl)propionic acid ethyl ester

: 1220514-58-8
C₂₇H₃₄FN₅O₃*ClH

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / 2-methyltetrahydrofuran; toluene / 0 - 24 °C / Large scale reaction

2.1: pyridine; sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 10 - 60 °C

4.1: hydrogenchloride / toluene / 25 - 35 °C

5.1: ethanol; ethyl acetate

6.1: triethylamine; sodium hydroxide / 2-methyltetrahydrofuran

6.2: 20 °C / Cooling with ice

7.1: hydrogenchloride / water; acetone / 3.5 h

With pyridine; hydrogenchloride; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetone; toluene; 2.1: Parikh-Doering oxidation;
DOI:10.1021/op100020z

Reference yield:

: 172739-04-7
cis-3-benzyl-3,7-diazabicyclo[3.3.0]octane

: 1220514-58-8
C₂₇H₃₄FN₅O₃*ClH

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate; dipotassium hydrogenphosphate / water; acetonitrile / 2 h / 0 °C / Large scale reaction

1.2: 10 °C / Large scale reaction

2.1: palladium 10% on activated carbon; hydrogen / methabol / 60 °C / 5931.67 Torr

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 10 - 60 °C

4.1: hydrogenchloride / toluene / 25 - 35 °C

5.1: ethanol; ethyl acetate

6.1: triethylamine; sodium hydroxide / 2-methyltetrahydrofuran

6.2: 20 °C / Cooling with ice

7.1: hydrogenchloride / water; acetone / 3.5 h

With hydrogenchloride; potassium phosphate; dipotassium hydrogenphosphate; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; dichloromethane; methabol; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/op100020z

Reference yield:

: 66838-42-4
(3R,S)-tetrahydro-furan-3-carboxylic acid

: 1220514-58-8
C₂₇H₃₄FN₅O₃*ClH

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 10 - 20 °C

2.1: triethylamine; sodium hydroxide / 2-methyltetrahydrofuran

2.2: 20 °C / Cooling with ice

3.1: hydrogenchloride / water; acetone / 3.5 h

With hydrogenchloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In 2-methyltetrahydrofuran; water; acetone; toluene;
DOI:10.1021/op100020z