benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Base Information

Chemical Name:benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate
CAS No.:106962-57-6
Molecular Formula:C₃₅H₃₀N₆O₁₂S
Molecular Weight:758.722
Hs Code.:

benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

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Chemical Property of benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

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Technology Process of benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

There total 3 articles about benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 106962-56-5,107034-14-0
2-((S)-4-{2-[2-(2-Chloro-acetylamino)-thiazol-4-yl]-2-[(Z)-4-nitro-benzyloxycarbonylmethoxyimino]-acetylamino}-3-oxo-isoxazolidin-2-yl)-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester

: 106962-57-6,107034-15-1,128899-33-2
benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Guidance literature:: With sodium N-methyldithiocarbamate; In tetrahydrofuran; water; for 1h; Ambient temperature;
DOI:10.1248/cpb.38.116

Reference yield:

: 106962-17-8,106962-18-9,115441-24-2
benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

: 106962-57-6,107034-15-1,128899-33-2
benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / HOBT, DCC / dimethylformamide / 0.67 h / Ambient temperature

2: 69 percent / sodium N-methyldithiocarbamate / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With sodium N-methyldithiocarbamate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.116

Reference yield:

: 84208-28-6
2-<2-<(chloroacetyl)amino>-4-thiazolyl>-(Z)-2-<<(p-nitrobenzyloxycarbonyl)methoxy>imino>acetic acid

: 106962-57-6,107034-15-1,128899-33-2
benzhydryl 2-<(4S)-4-<2-(2-amino-4-thiazolyl)-(Z)-2-(4-nitrobenzyloxycarbonylmethoxyimino)acetylamino>-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / HOBT, DCC / dimethylformamide / 0.67 h / Ambient temperature

2: 69 percent / sodium N-methyldithiocarbamate / tetrahydrofuran; H₂O / 1 h / Ambient temperature

With sodium N-methyldithiocarbamate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.116