(+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate

Base Information

• Chemical Name: (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate
• CAS No.: 94668-89-0
• Molecular Formula: C₇H₁₆N₂O₃*H₂O₄S
• Molecular Weight: 274.295
• Mol file: 94668-89-0.mol

Synonyms:

Chemical Property of (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate

There total 5 articles about (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1α,2α,3β,4α,5α)-1,2:4,5-dianhydro-1,2,3,4,5-cyclohexane-pentol (55990-89-1,261919-41-9) → (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate (94668-89-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / dioxane / 6 h / Heating

2: chiral phase transfer catalyst, KOH / dioxane / 23 °C

3: 49 percent / propan-1-ol / 5 h / Heating

4: conc. HCl, H₂ / Pd/C / methanol / 8 h / Ambient temperature

5: 1) Ba(OH)2, 2) H₂SO₄ / 1) CH₃OH/H₂O, reflux, 5 h, 2) CH₃OH, H₂O

With hydrogenchloride; barium dihydroxide; potassium hydroxide; chiral phase transfer catalyst; sulfuric acid; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; propan-1-ol;

Reference yield:

DL-(1α,2α,3β,4β,5α)-1,2-anhydro-3-O,4-N-carbonyl-4-(methylamino)-1,2,3,5-cyclohexanetetrol (94592-12-8) → (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate (94668-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / propan-1-ol / 5 h / Heating

2: conc. HCl, H₂ / Pd/C / methanol / 8 h / Ambient temperature

3: 1) Ba(OH)2, 2) H₂SO₄ / 1) CH₃OH/H₂O, reflux, 5 h, 2) CH₃OH, H₂O

With hydrogenchloride; barium dihydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; propan-1-ol;

Reference yield:

(1α,2α,3β,4α,5α)-1,2:4,5-dianhydro-3-O-(methylcarbamoyl)-1,2,3,4,5-cyclohexane-pentol (94592-11-7) → (+)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-3-(methylammonio)-1,2,4-cyclohexanetriol sulfate (94668-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: chiral phase transfer catalyst, KOH / dioxane / 23 °C

2: 49 percent / propan-1-ol / 5 h / Heating

3: conc. HCl, H₂ / Pd/C / methanol / 8 h / Ambient temperature

4: 1) Ba(OH)2, 2) H₂SO₄ / 1) CH₃OH/H₂O, reflux, 5 h, 2) CH₃OH, H₂O

With hydrogenchloride; barium dihydroxide; potassium hydroxide; chiral phase transfer catalyst; sulfuric acid; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; propan-1-ol;

upstream raw materials:

(-)-(1R)-(1α,2β,3β,4α,6β)-6-ammonio-2-O,3-N-carbonyl-3-(methylamino)-1,2,4-cyclohexanetriol chloride

(1α,2α,3β,4α,5α)-1,2:4,5-dianhydro-1,2,3,4,5-cyclohexane-pentol

DL-(1α,2α,3β,4β,5α)-1,2-anhydro-3-O,4-N-carbonyl-4-(methylamino)-1,2,3,5-cyclohexanetetrol

(1α,2α,3β,4α,5α)-1,2:4,5-dianhydro-3-O-(methylcarbamoyl)-1,2,3,4,5-cyclohexane-pentol